Size and Predictive Factors of Microscopic Tumor Extension in Locally Advanced Non-Small Cell Lung Cancer
| Autor: | Nicolas Giraud, Claire Meynard, Catherine Durdux, Audrey Mansuet-Lupo, Armelle Guénégou-Arnoux, Diane Damotte, Geoffroy Boulle, P. Giraud, Paul Imbault, Antonio Bobbio |
|---|---|
| Přispěvatelé: | Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), HAL-SU, Gestionnaire |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Lung Neoplasms medicine.medical_treatment Cell Planning target volume Locally advanced Magnification Adenocarcinoma 030218 nuclear medicine & medical imaging 03 medical and health sciences Computed Tomography 0302 clinical medicine Microscopic tumoral extension Non-small cell lung cancer Carcinoma Non-Small-Cell Lung Nodal status Humans Medicine Radiology Nuclear Medicine and imaging Lung cancer Conformal radiation therapy Neoplasm Staging Retrospective Studies [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology MESH: Humans business.industry MESH: Adenocarcinoma MESH: Carcinoma Squamous Cell MESH: Retrospective Studies MESH: Neoplasm Staging medicine.disease MESH: Lung Neoplasms 3. Good health Radiation therapy medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Non small cell Radiology business Clinical Target Volume MESH: Carcinoma Non-Small-Cell Lung [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Practical Radiation Oncology: An official journal of the American Society for Radiation Oncology Practical Radiation Oncology: An official journal of the American Society for Radiation Oncology, Elsevier, 2021, 11 (6), pp.491-501. ⟨10.1016/j.prro.2021.05.006⟩ |
| ISSN: | 1879-8500 |
| Popis: | International audience; Purpose: Radiation therapy for locally advanced non-small cell lung cancer (NSCLC) should treat the whole tumor, including its microscopic extensions, and protect adjacent organs at risk as much as possible. The aim of our study is to evaluate the size of microscopic tumor extension (MEmax) in NSCLC, and search for potential predictive factors.Methods and materials: We retrospectively selected 70 patients treated with postoperative radiation therapy for a NSCLC with N2 nodal status, then 34 additional patients operated for a squamous cell lung cancer with N1 or N2 nodal status. On the digitized slides originating from the resected tumors of these 104 patients, we outlined the border of the tumor, as seen with the naked eye. We then searched for microscopic tumor extension outside of these borders with a magnification as high as 40 × and measured the maximum size of MEmax.Results: The median MEmax in the whole cohort was 0.85 mm (0-9.95). The MEmax was |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|