Magnesium pyrophosphates in enzyme mimics of nucleotide synthases and kinases and in their prebiotic chemistry
| Autor: | Vijayakumar Ramalingam, Ronald Breslow, Purushothaman Gopinath |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
Multidisciplinary Molecular Structure Nucleotides Magnesium Kinase Methanol Ribose Phosphoribosyl pyrophosphate Molecular Mimicry Origin of Life Magnesium Compounds chemistry.chemical_element Pyrophosphate Diphosphates chemistry.chemical_compound Adenosine Triphosphate Biochemistry chemistry Physical Sciences Phosphorylation Nucleotide Adenosine triphosphate |
| Zdroj: | Proceedings of the National Academy of Sciences. 112:12011-12014 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.1516239112 |
| Popis: | Significance Nucleotides are biosynthesized from a ribose pyrophosphate species, with enzymes and magnesium ions as catalysts. Magnesium ions alone can perform this process with synthetic ribose pyrophosphates, by binding to the pyrophosphate groups and linking cyclic nitrogen bases to the ribose. In a kinase mimic ATP transfers the terminal phosphate to receptors catalyzed by magnesium ions, binding to pyrophosphate groups, but magnesium ion at low concentrations inhibits the process, and only at higher concentrations is it a catalyst. This affords great insight into the mechanism of ATP phosphorylation, a fundamental biological process. Our enzyme mimics could well operate on prebiotic earth before enzymes were present. This work strengthens the picture of how important components of life could have been formed prebiotically. |
| Databáze: | OpenAIRE |
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