Antibacterial and antioxidant activities of a novel enol ether nor-sesquiterpene isolated from Myrtus nivellei Batt.Trab
| Autor: | Chawki Benssouici, Simon Bordage, Jennifer Samaillie, Abederrahmane Bensegueni, Christel Neut, Sevser Sahpaz, Rym Gouta Demmak, Mamdouh Abdel-Mogib |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
DPPH
Phytochemicals Microbial Sensitivity Tests Chemical Fractionation medicine.disease_cause Ether Antioxidants chemistry.chemical_compound Drug Discovery medicine Pharmacology Chromatography Minimum bactericidal concentration biology Molecular Structure Plant Extracts Pathogenic bacteria General Medicine Acinetobacter Plant Components Aerial biology.organism_classification Myrtus Anti-Bacterial Agents Stenotrophomonas maltophilia chemistry Staphylococcus aureus Algeria Desert Climate Antibacterial activity Sesquiterpenes Bacteria |
| Zdroj: | Fitoterapia. 153 |
| ISSN: | 1873-6971 |
| Popis: | Myrtus nivellei is a plant traditionally used to treat diseases including infection of microbial origin. Several M. nivellei Batt. & Trab. extracts (dichloromethane, methanol and ethanol/water) were screened for their activity against 36 microorganisms, including strains resistant to antibiotics. These extracts inhibited on average 15 bacteria strains with minimum inhibition concentrations (MICs) ranging from 0.07 to 1.20 mg/mL. Bioassay guided fractionation was carried out with bioautography on TLC plates using four pathogenic bacteria strains, and following chromatographies (CPC and HPLC) led to the isolation of two novel enol ether nor-cadinane sesquiterpenes from the dichloromethane extract. The major compound (1) showed a strong antibacterial activity. Minimal inhibition concentration and minimal bactericidal concentration (MBC) values were determined against four bacteria: Acinetobacter baumanii, Stenotrophomonas maltophilia, Yersinia pseudotuberculosis and Staphylococcus lugdunensis. The best activity was observed against Acinetobacter baumanii with a MIC value of 9.7 μg/mL. This novel compound was also very active against a Staphylococcus aureus strain resistant to amoxicillin (MIC 19.5 μg/mL). In addition, compound 1 showed a very high antioxidant activity with both DPPH and metal chelate methods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect