Comparison of Cold-Knife Conization versus Loop Electrosurgical Excision for Cervical Adenocarcinoma In Situ (ACIS): A Systematic Review and Meta-Analysis

Autor: Yan-Ming Jiang, Chang-Xian Chen, Li Li
Rok vydání: 2016
Předmět:
Electrosurgery
medicine.medical_treatment
Conization
lcsh:Medicine
Uterine Cervical Neoplasms
Cryosurgery
Database and Informatics Methods
0302 clinical medicine
Mathematical and Statistical Techniques
Adenocarcinomas
Medicine and Health Sciences
Reproductive System Procedures
Database Searching
Prospective cohort study
lcsh:Science
030219 obstetrics & reproductive medicine
Multidisciplinary
Fertility Preservation
Research Assessment
Systematic review
Oncology
Research Design
030220 oncology & carcinogenesis
Meta-analysis
Physical Sciences
Female
Statistics (Mathematics)
Research Article
medicine.medical_specialty
China
Systematic Reviews
Surgical and Invasive Medical Procedures
Adenocarcinoma in Situ
Hysterectomy
Research and Analysis Methods
Carcinomas
03 medical and health sciences
medicine
Humans
Statistical Methods
Retrospective Studies
Surgical Excision
business.industry
lcsh:R
Cancers and Neoplasms
Retrospective cohort study
Surgery
Sample size determination
lcsh:Q
Neoplasm Recurrence
Local
business
Mathematics
Meta-Analysis
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 1, p e0170587 (2017)
ISSN: 1932-6203
Popis: Objective The objective of this systematic review was to conduct a more comprehensive literature search and meta-analysis of original studies to evaluate the efficacy and safety of the loop electrosurgical excision procedure (LEEP) versus cold-knife conization (CKC) in conservative surgical treatment of cervical adenocarcinoma in situ (ACIS) for women who have not completed childbearing. Methods Systematic searches were conducted in the PUBMED, EMBASE, Cochrane, and China National Knowledge Infrastructure (CNKI) databases to identify all potential studies involving patients with ACIS treated with LEEP versus CKC published until December 2015. Results Eighteen retrospective studies were included in this systematic review. All the 18 included studies reported the rate of positive margins, and the results of the individual studies varied. The positive margins were 44% (267/607) after LEEP and 29% (274/952) after CKC. The pooled meta-analysis exhibited significantly different outcome (RR, 1.55; 95% CI, 1.34–1.80, P
Databáze: OpenAIRE
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