Comparison of Cold-Knife Conization versus Loop Electrosurgical Excision for Cervical Adenocarcinoma In Situ (ACIS): A Systematic Review and Meta-Analysis
Autor: | Yan-Ming Jiang, Chang-Xian Chen, Li Li |
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Rok vydání: | 2016 |
Předmět: |
Electrosurgery
medicine.medical_treatment Conization lcsh:Medicine Uterine Cervical Neoplasms Cryosurgery Database and Informatics Methods 0302 clinical medicine Mathematical and Statistical Techniques Adenocarcinomas Medicine and Health Sciences Reproductive System Procedures Database Searching Prospective cohort study lcsh:Science 030219 obstetrics & reproductive medicine Multidisciplinary Fertility Preservation Research Assessment Systematic review Oncology Research Design 030220 oncology & carcinogenesis Meta-analysis Physical Sciences Female Statistics (Mathematics) Research Article medicine.medical_specialty China Systematic Reviews Surgical and Invasive Medical Procedures Adenocarcinoma in Situ Hysterectomy Research and Analysis Methods Carcinomas 03 medical and health sciences medicine Humans Statistical Methods Retrospective Studies Surgical Excision business.industry lcsh:R Cancers and Neoplasms Retrospective cohort study Surgery Sample size determination lcsh:Q Neoplasm Recurrence Local business Mathematics Meta-Analysis |
Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 1, p e0170587 (2017) |
ISSN: | 1932-6203 |
Popis: | Objective The objective of this systematic review was to conduct a more comprehensive literature search and meta-analysis of original studies to evaluate the efficacy and safety of the loop electrosurgical excision procedure (LEEP) versus cold-knife conization (CKC) in conservative surgical treatment of cervical adenocarcinoma in situ (ACIS) for women who have not completed childbearing. Methods Systematic searches were conducted in the PUBMED, EMBASE, Cochrane, and China National Knowledge Infrastructure (CNKI) databases to identify all potential studies involving patients with ACIS treated with LEEP versus CKC published until December 2015. Results Eighteen retrospective studies were included in this systematic review. All the 18 included studies reported the rate of positive margins, and the results of the individual studies varied. The positive margins were 44% (267/607) after LEEP and 29% (274/952) after CKC. The pooled meta-analysis exhibited significantly different outcome (RR, 1.55; 95% CI, 1.34–1.80, P |
Databáze: | OpenAIRE |
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