[3H]phytic acid (inositol hexaphosphate) is absorbed and distributed to various tissues in rats
| Autor: | Kosaku Sakamoto, Ivana Vucenik, Abulkalam M. Shamsuddin |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Phytic Acid Medicine (miscellaneous) Biology Intestinal absorption chemistry.chemical_compound Internal medicine medicine Ingestion Animals Inositol Tissue Distribution Inositol phosphate chemistry.chemical_classification Gastrointestinal tract Phytic acid Nutrition and Dietetics Stomach Chromatography Ion Exchange Small intestine Rats Inbred F344 Rats medicine.anatomical_structure Endocrinology chemistry Intestinal Absorption Autoradiography Digestive System |
| Zdroj: | The Journal of nutrition. 123(4) |
| ISSN: | 0022-3166 |
| Popis: | To understand the mechanism of antineoplastic action of phytic acid, we investigated the absorption and distribution of myo-[inositol-2-3H(N)] hexakisphosphate in rats. The radioactivity was measured in urine, feces, blood, gastrointestinal tract contents and various organs and tissues at 1 and 24 h after intragastric administration. Of the total radioactivity, 79.0 +/- 10.0% was absorbed and at least 26.6% was degraded during the 24-h period following ingestion. The absorption was rapid; 11.0 +/- 2.6% of the radioactivity was detected in the wall of the stomach (4.4 +/- 3.7%) and upper small intestine (6.6 +/- 1.9%), 6.5 +/- 2.6% in the skeletal muscle and 4.0 +/- 1.5% in the skin after 1 h. Much of the radioactivity after 24 h was in the liver (4.0 +/- 0.9%), kidneys (2.2 +/- 1.1%), muscle (18.1 +/- 3.4%) and skin (10.1 +/- 3.3%). Analysis of plasma and urine demonstrated that most of the radioactivity was due to myo-inositol and small amounts of inositol monophosphate (InsP1). Gastric epithelial cells, however, contained inositol and various inositol phosphates (InsP1-6). Our data suggest that soluble InsP6 when administered in drinking water is rapidly absorbed through the stomach and upper small intestine, becomes quickly dephosphorylated within the mucosal cells and is distributed to various organs as inositol and InsP1. |
| Databáze: | OpenAIRE |
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