The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency
| Autor: | Zvi Laron |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
endocrine system
medicine.medical_specialty Endocrinology Diabetes and Metabolism media_common.quotation_subject Longevity Population Dwarfism IGF1 Deficiency Neoplasms Internal medicine Laron syndrome Humans Medicine Insulin-Like Growth Factor I education media_common Cause of death education.field_of_study Human Growth Hormone business.industry Cancer General Medicine medicine.disease Obesity Laron Syndrome Endocrinology business hormones hormone substitutes and hormone antagonists |
| Zdroj: | HORMONES. 7:24-27 |
| ISSN: | 1109-3099 |
| Popis: | Primary or secondary IGF1 deficiency has been implicated in shortening of lifespan. This paper reviews available data on the influence of IGF1 deficiency on lifespan and longevity in animals and man. It has been shown that inactivation of the IGF1 gene or of the GH receptor in both invertebrates (C-elegans, flies-Drosphila) and rodents (mice and rats), leading to IGF1 deficiency, prolong life, particularly in females. In man, evaluation of the 2 largest cohorts of patients with Laron syndrome (inactive GH receptor resulting in IGF1 deficiency) in Israel and Ecuador revealed that despite their dwarfism and marked obesity, patients are alive at the ages of 75-78 years, with some having reached even more advanced ages. It is assumed that a major contributing factor is their protection from cancer, a major cause of death in the general population. |
| Databáze: | OpenAIRE |
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