Increased lipoprotein X causes hyperlipidemia during intravenous administration of 10% fat emulsion in man
| Autor: | Kazuo Horibe, Tsuguhiko Tashiro, Masahiko Nishizawa, Masao Sanada, Hideo Yamamori, Katsuji Okui, Yoshiya Mashima |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Fat Emulsions Intravenous 030309 nutrition & dietetics Phospholipid Medicine (miscellaneous) Hyperlipidemias 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Hyperlipidemia medicine Humans Phospholipids Aged 0303 health sciences Lipoprotein-X Nutrition and Dietetics Triglyceride business.industry Cholesterol Middle Aged medicine.disease Lipids Pathophysiology Parenteral nutrition Endocrinology Apolipoproteins chemistry lipids (amino acids peptides and proteins) 030211 gastroenterology & hepatology Female Parenteral Nutrition Total business Lipoprotein |
| Zdroj: | JPEN. Journal of parenteral and enteral nutrition. 15(5) |
| ISSN: | 0148-6071 |
| Popis: | To clarify the mechanisms of hyperlipidemia during intravenous Intralipid 10%, lipoprotein profiles including lipoprotein X were studied in 13 patients receiving 2.0 g of fat per kilogram per day by Intralipid 10% over a period of 8 weeks. All patients were fed exclusively by total parenteral nutrition providing 1.1 g of amino acid and 30 kcal/kg per day. Intravenous administration of Intralipid 10% caused a marked increase of low-density lipoprotein (LDL), phospholipid, and cholesterol, especially free cholesterol, whereas triglyceride, very-low-density lipoprotein, and high-density lipoprotein remained within the normal range. Lipid composition of LDL approximated that of lipoprotein X progressively with the intravenous Intralipid 10%. Quantification of lipoprotein X revealed that its increase was proportionate with that of LDL and total lipid. From these findings, hyperlipidemia during intravenous Intralipid 10% is induced almost exclusively by the increased lipoprotein X. |
| Databáze: | OpenAIRE |
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