Circulating CD4+PD-1+ and CD8+PD-1+ T cells are profoundly decreased at the onset of fulminant type 1 diabetes and are restored by treatment, contrasting with CD4+CD25+FoxP3+ regulatory T cells
| Autor: | Maiko Fukushima, Toshie Iijima, Teruo Jojima, Takanori Tomotsune, Kunihiro Suzuki, Yoshimasa Aso, Kanako Kato |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Programmed cell death endocrine system diseases Endocrinology Diabetes and Metabolism Fulminant CD8 Antigens Programmed Cell Death 1 Receptor 030209 endocrinology & metabolism T-Lymphocytes Regulatory 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Humans Receptor Aged Type 1 diabetes biology business.industry FOXP3 General Medicine medicine.disease 030104 developmental biology Diabetes Mellitus Type 1 CD4 Antigens biology.protein Female Antibody business CD8 |
| Zdroj: | Diabetes research and clinical practice. 133 |
| ISSN: | 1872-8227 |
| Popis: | Programed cell death protein-1 (PD-1) is an inhibitory receptor expressed by T cells that downregulates the activation and proliferation of these cells to maintain peripheral self-tolerance. Recent studies reported some cases of new-onset type 1 diabetes (T1D) under anti-PD1 or PDL-1 antibodies. We demonstrated that circulating both CD4+PD-1+ and CD8+PD-1+ T cells were profoundly reduced at the onset of fulminant T1D and were restored by treatment in two patients with fulminant T1D. |
| Databáze: | OpenAIRE |
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