Risk assessment of aflatoxins in food
Autor: | EFSA CONTAM Panel, Schrenk, Dieter, Bignami, Margherita, Bodin, Laurent, Chipman, James Kevin, Del Mazo, Jesús, Grasl-Kraupp, Bettina, Hogstrand, Christer, Hoogenboom, Laurentius (Ron), Leblanc, Jean-Charles, Nebbia, Carlo Stefano, Nielsen, Elsa, Ntzani, Evangelia, Petersen, Annette, Sand, Salomon, Schwerdtle, Tanja, Vleminckx, Christiane, Marko, Doris, Oswald, Isabelle P., Piersma, Aldert, Routledge, Michael, Schlatter, Josef, Baert, Katleen, Gergelova, Petra, Wallace, Heather |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Aflatoxin
Younger age margin of exposure (MOE) Novel Foods & Agrochains BU Toxicologie 040301 veterinary sciences Veterinary (miscellaneous) TP1-1185 Plant Science 010501 environmental sciences Novel Foods & Agroketens liver occurrence 01 natural sciences Microbiology Expert committee 0403 veterinary science Environmental health Fermented milk products Medicine Potency cancer TX341-641 BU Toxicology Novel Foods & Agrochains aflatoxin exposure food VLAG 0105 earth and related environmental sciences Nutrition. Foods and food supply business.industry Chemical technology Incidence (epidemiology) BU Toxicology food and beverages 04 agricultural and veterinary sciences Confidence interval Scientific Opinion BU Toxicologie Novel Foods & Agroketens Animal Science and Zoology Parasitology business Risk assessment Food Science |
Zdroj: | EFSA Journal, Vol 18, Iss 3, Pp n/a-n/a (2020) EFSA Journal 18 (2020) 3 EFSA Journal, 18(3) EFSA Journal |
ISSN: | 1831-4732 |
Popis: | EFSA was asked to deliver a scientific opinion on the risks to public health related to the presence of aflatoxins in food. The risk assessment was confined to aflatoxin B1 (AFB1), AFB2, AFG1, AFG2 and AFM1. More than 200,000 analytical results on the occurrence of aflatoxins were used in the evaluation. Grains and grain‐based products made the largest contribution to the mean chronic dietary exposure to AFB1 in all age classes, while ‘liquid milk’ and ‘fermented milk products’ were the main contributors to the AFM1 mean exposure. Aflatoxins are genotoxic and AFB1 can cause hepatocellular carcinomas (HCCs) in humans. The CONTAM Panel selected a benchmark dose lower confidence limit (BMDL) for a benchmark response of 10% of 0.4 μg/kg body weight (bw) per day for the incidence of HCC in male rats following AFB1 exposure to be used in a margin of exposure (MOE) approach. The calculation of a BMDL from the human data was not appropriate; instead, the cancer potencies estimated by the Joint FAO/WHO Expert Committee on Food Additives in 2016 were used. For AFM1, a potency factor of 0.1 relative to AFB1 was used. For AFG1, AFB2 and AFG2, the in vivo data are not sufficient to derive potency factors and equal potency to AFB1 was assumed as in previous assessments. MOE values for AFB1 exposure ranged from 5,000 to 29 and for AFM1 from 100,000 to 508. The calculated MOEs are below 10,000 for AFB1 and also for AFM1 where some surveys, particularly for the younger age groups, have an MOE below 10,000. This raises a health concern. The estimated cancer risks in humans following exposure to AFB1 and AFM1 are in‐line with the conclusion drawn from the MOEs. The conclusions also apply to the combined exposure to all five aflatoxins. This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2020.EN-1798/full |
Databáze: | OpenAIRE |
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