Biomarkers of lipid peroxidation related to hypertension in aging
| Autor: | Deniz Suna Erdinçler, Serap Yavuzer, Huriye Balci, Hafize Uzun, Mahir Cengiz, Alper Döventaş, Hakan Yavuzer, Hayriye Erman |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Aging Lipid Peroxides medicine.medical_specialty Antioxidant Physiology medicine.medical_treatment Cardiovascular risk factors 030204 cardiovascular system & hematology Dinoprost Carotid Intima-Media Thickness Risk Assessment Sensitivity and Specificity Thiobarbituric Acid Reactive Substances Lipid peroxidation 03 medical and health sciences Increased lipid chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine Healthy volunteers Internal Medicine medicine TBARS Humans Aged Aged 80 and over business.industry Middle Aged Healthy Volunteers Surgery 030104 developmental biology Blood pressure Endocrinology chemistry Intima-media thickness Hypertension Female Lipid Peroxidation Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Hypertension Research. 39:342-348 |
| ISSN: | 1348-4214 0916-9636 |
| DOI: | 10.1038/hr.2015.156 |
| Popis: | The aim of this clinical study was to evaluate the influence of aging on the levels of lipid peroxidation (quantified as thiobarbituric acid-reactive substances (TBARS) content), lipid hydroperoxide (LOOH), hexanoyl lysine (HEL), 8-iso-prostaglandin F2α (8-iso-PGF2α) and total antioxidant capacity (TAC), and determine their relationships to the demographic and cardiovascular risk factors in elderly hypertensive (HT) patients. This study consisted of four groups: two elderly groups with 30 HT patients (11 males, 19 females) and 30 normotensive healthy volunteers (15 males, 15 females), and two young groups with 30 HT patients (13 males, 17 females) and 30 normotensive healthy volunteers (12 males, 18 females). In the elderly control group, the TBARS, LOOH, HEL and 8-iso-PGF2α levels, and the carotid intima media thickness (CIMT) were significantly higher than in the young control group. The TBARS, LOOH, HEL and 8-iso-PGF2α levels and the CIMT measurements were significantly higher in the elderly HT group than in the young HT group. In addition, the TAC levels were significantly lower in the elderly and young HT groups than in the elderly and young control groups. The CIMT was significantly positively correlated with TBARS (r=0.40, P |
| Databáze: | OpenAIRE |
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