GLC Determination of Degradation of Two Related Amine Uptake Inhibitors

Autor:	Rex W. Souter, Alan Dinner
Rok vydání:	1976
Předmět:	Chromatography Gas Propylamines Computers Chemistry Phenyl Ethers Kinetics Pharmaceutical Science Mass Spectrometry Drug Stability Basic solution Methods CNS agents Organic chemistry Degradation (geology) Amine gas treating Acid hydrolysis
Zdroj:	Journal of Pharmaceutical Sciences. 65:457-459
ISSN:	0022-3549
DOI:	10.1002/jps.2600650341
Popis:	A convenient GLC method was developed to assay the chemically related CNS agents dl ‐3‐( p ‐trifluoromethylphenoxy)‐ N ‐methyl‐3‐phenylpropylamine (Ia) and dl ‐3‐( o ‐methoxy‐phenoxy)‐ N ‐methyl‐3‐phenylpropylamine (Ib). Subsequently, this GLC method was used to monitor the stability of Ia and Ib in acidic and basic media. These CNS agents were stable in basic solution but labile under acid conditions, and the degradations of both compounds approximated pseudo‐first‐order kinetics. Products formed during the acid hydrolysis of Ia and Ib were identified and were shown not to interfere in the GLC assays of the parent ethers.
Databáze:	OpenAIRE
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