The synthesis of coumarin thiazoles containing a trifluoromethyl group and their antifungal activities
| Autor: | Cuilian Xu, Guoyu Yang, Lulu Wu, Lijun Shi, Jun Liang, Liangxin Fan, Zhenliang Pan, Caixia Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Fusarium
Antifungal medicine.drug_class General Chemical Engineering 02 engineering and technology 010402 general chemistry 01 natural sciences Medicinal chemistry Fungicidal activity Trifluoromethyl lcsh:Chemistry chemistry.chemical_compound Group (periodic table) medicine Solvent-free biology Coumarin thiazoles General Chemistry Carbon-13 NMR 021001 nanoscience & nanotechnology biology.organism_classification Coumarin 0104 chemical sciences chemistry lcsh:QD1-999 Curvularia Proton NMR 0210 nano-technology |
| Zdroj: | Arabian Journal of Chemistry, Vol 14, Iss 1, Pp 102880-(2021) |
| ISSN: | 1878-5352 |
| Popis: | A series of novel coumarin thiazoles containing trifluoromethyl group 3a-3l were prepared through a one-pot reaction using 3-(trifluoroacetyl)coumarin as a starting material in solvent-free conditions. Their structures were confirmed using IR, 1H NMR, 13C NMR, HRMS and X-ray single crystal diffraction, and their antifungal activity against Fusarium. moniliforme(F. moniliforme), Fusarium. graminearum (F. graminearum), and Curvularia. lunata (C. lunata) was evaluated. Among the synthesized compounds, compound 3f showed the highest inhibitor rate of 74% at 0.5 mg/mL against F. moniliforme, and compound 3g exhibited the highest inhibitor rates of 89% and 93.4% at 0.5 mg/mL against F. graminearum and C. lunata, respectively. The introduction of trifluoromethyl group greatly improved the antifungal activity of counterpart 3g compared to the compound 4. |
| Databáze: | OpenAIRE |
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