PPARalpha gene variation and physical performance in Russian athletes
| Autor: | Olga Vinogradova, Aleksei I Netreba, Anastasia B Vdovina, Ekaterina V. Lyubaeva, Irina A. Mozhayskaya, Pavel P. Tarakin, Ildus I. Ahmetov, David M. Flavell, Daniil V. Popov, Hugh Montgomery, Boris Shenkman, Irina V. Astratenkova, V. A. Rogozkin, Antonina I Komkova |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Russia chemistry.chemical_compound Polymorphism (computer science) Physiology (medical) Internal medicine Genotype medicine Humans Orthopedics and Sports Medicine PPAR alpha Allele Muscle Skeletal Allele frequency biology Fatty acid metabolism Athletes Public Health Environmental and Occupational Health Genetic Variation General Medicine biology.organism_classification Genotype frequency Endocrinology chemistry Physical Endurance Female Anaerobic exercise Psychomotor Performance Sports |
| Zdroj: | European journal of applied physiology. 97(1) |
| ISSN: | 1439-6319 |
| Popis: | Peroxisome proliferator-activated receptor alpha (PPARalpha) regulates genes responsible for skeletal and heart muscle fatty acid oxidation. Previous studies have shown that the PPARalpha intron 7 G/C polymorphism was associated with left ventricular growth in response to exercise. We speculated that GG homozygotes should be more prevalent within a group of endurance-oriented athletes, have normal fatty acid metabolism, and increased percentages of slow-twitch fibers. We have tested this hypothesis in the study of a mixed cohort of 786 Russian athletes in 13 different sporting disciplines prospectively stratified by performance (endurance-oriented athletes, power-oriented athletes and athletes with mixed endurance/power activity). PPARalpha intron 7 genotype and allele frequencies were compared to 1,242 controls. We found an increasing linear trend of C allele with increasing anaerobic component of physical performance (P=0.029). GG genotype frequencies in endurance-oriented and power-oriented athletes were 80.3 and 50.6%, respectively, and were significantly (P0.0001) different compared to controls (70.0%). To examine the association between PPARalpha gene variant and fiber type composition, muscle biopsies from m. vastus lateralis were obtained and analyzed in 40 young men. GG homozygotes (n=25) had significantly (P=0.003) higher percentages of slow-twitch fibers (55.5+/-2.0 vs 38.5+/-2.3%) than CC homozygotes (n=4). In conclusion, PPARalpha intron 7 G/C polymorphism was associated with physical performance in Russian athletes, and this may be explained, in part, by the association between PPARalpha genotype and muscle fiber type composition. |
| Databáze: | OpenAIRE |
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