A novel guluronate oligomer improves intestinal transit and survival in cystic fibrosis mice
| Autor: | Edvar Onsoyen, A.H. Myrset, Philip D. Rye, Mitchell L. Drumm, Craig A. Hodges, Megan Vitko, Arne Dessen, Dana M. Valerio |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Genetically modified mouse Cystic Fibrosis Alginates Cystic Fibrosis Transmembrane Conductance Regulator Oligosaccharides Intestinal Secretions chemistry.chemical_element Calcium Cystic fibrosis Microbiology Mice 03 medical and health sciences Intestine Small medicine Animals Gastrointestinal Transit biology business.industry Mucin Wild type medicine.disease Mucus Cystic fibrosis transmembrane conductance regulator Treatment Outcome 030104 developmental biology chemistry Pediatrics Perinatology and Child Health Immunology biology.protein business |
| Zdroj: | Journal of Cystic Fibrosis. 15:745-751 |
| ISSN: | 1569-1993 |
| Popis: | Background Cystic fibrosis (CF) patients experience intestinal complications characterized by the accumulation of thick viscous mucus. CF mice were utilized to determine if a novel guluronate oligomer, OligoG, may be a potential therapy in reducing intestinal mucus and subsequent CF-related intestinal manifestations. Methods Intestinal transit, intestinal histology, survival and growth were examined in wildtype and CF mice on regular water and OligoG. Conclusions OligoG improves intestinal transit and survival in CF mice by reducing the accumulation of intestinal mucus. OligoG's ability to directly bind mucin, disrupt mucin interaction and/or sequester calcium allowing for mucin expansion may explain the decrease in mucus accumulation. |
| Databáze: | OpenAIRE |
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