Nucleotide modifications in messenger RNA and their role in development and disease
| Autor: | Veronica Dezi, Irmgard U. Haussmann, Chavdar Ivanov, Matthias Soller |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Arabidopsis Saccharomyces cerevisiae Biology Biochemistry 03 medical and health sciences Animals Humans Disease Genetic Predisposition to Disease Nucleotide RNA Messenger Caenorhabditis elegans Gene Genetics chemistry.chemical_classification Messenger RNA Nucleotides mRNA surveillance Reverse genetics Drosophila melanogaster 030104 developmental biology chemistry RNA editing Mutation RNA Editing MRNA methylation Function (biology) |
| Zdroj: | Biochemical Society Transactions. 44:1385-1393 |
| ISSN: | 1470-8752 0300-5127 |
| DOI: | 10.1042/bst20160110 |
| Popis: | Modified nucleotides in messenger RNA (mRNA) have been discovered over 40 years ago, but until recently little was known about which transcripts contain them and what their function is. High-throughput sequencing approaches revealed a dynamic landscape of the ‘Epitranscriptome’ for many mRNA modifications in various organisms from yeast to humans. Meanwhile, also many genes encoding mRNA-modifying enzymes and auxiliary proteins have been identified yielding functional insights by reverse genetics into their role in development and disease. |
| Databáze: | OpenAIRE |
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