High immune responsiveness in a family with multiple paraproteinemia and autoimmune thyroid-disease
| Autor: | J. Weits, G. C. Gast, T. H. The, M. Giessen, Th. Ockhuizen, J. J. M. Festen, E. Mandema |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Paraproteinemias Immunoglobulins chemical and pharmacologic phenomena Lymphocyte proliferation Lymphocyte Activation medicine.disease_cause Autoimmune Diseases Immune system Internal medicine Internal Medicine medicine Humans Aged Phytohaemagglutinin Immunity Cellular biology business.industry Thyroid disease Middle Aged Immune dysregulation medicine.disease Thyroid Diseases Anti-thyroid autoantibodies Endocrinology Immunization Immunology biology.protein Female Antibody business |
| Zdroj: | Journal of Internal Medicine, 208(3), 169-175. Wiley |
| ISSN: | 0954-6820 |
| Popis: | Immune responsiveness was investigated in a family comprising 12 first- and second-degree relatives, one of whom had k-myelomatosis, one igA-λ paraproteinaemia, two Graves' disease and a further two thyroid antibodies without disease. Relatives by marriage served as controls. Parameters of immune capacity studied were the humoral and cellular immune response to haemo-cyanin of Helix pomatia (HPH), dinitrochloroben-zene (DNCB) skin reactivity and in vitro lymphocyte proliferation capacity to phytohaemagglutinin (PHA). Mean antibody titres to HPH were higher in the family than in the control group in all main Ig classes and IgG subclasses after primary and secondary immunization, and the difference was statistically significant for IgG, IgG2 and IgG4 titres. This could not have been predicted from the (normal) serum Ig levels in this family. In vitro lymphocyte proliferation capacity to HPH after primary and secondary immunization was also significantly increased. DNCB skin reactivity also tended to be high in the family, whereas PHA-induced lymphocyte proliferation was normal. These findings support the idea that myelomatosis clusters in families with immune dysregulation. |
| Databáze: | OpenAIRE |
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