| Autor: |
Nameer Al-Yousif, Saketram Komanduri, Hafiz Qurashi, Anatoliy Korzhuk, Halimat O. Lawal, Nicholas Abourizk, Caitlin Schaefer, Kevin J. Mitchell, Catherine M. Dietz, Ellen K. Hughes, Clara S. Brandt, Georgia M. Fitzgerald, Robin Joyce, Asmaa S. Chaudhry, Daniel Kotok, Jose D. Rivera, Andrew I. Kim, Shruti Shettigar, Allen Lavina, Christine E. Girard, Samantha R. Gillenwater, Anas Hadeh, William Bain, Faraaz A. Shah, Matthew Bittner, Michael Lu, Niall Prendergast, John Evankovich, Konstantin Golubykh, Navitha Ramesh, Jana J. Jacobs, Cathy Kessinger, Barbara Methé, Janet S. Lee, Alison Morris, Bryan J. McVerry, Georgios D. Kitsios |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
medRxiv |
| Popis: |
INTRODUCTIONChest imaging is necessary for diagnosis of COVID-19 pneumonia, but current risk stratification tools do not consider radiographic severity. We quantified radiographic heterogeneity among inpatients with COVID-19 with the Radiographic Assessment of Lung Edema (RALE) score on Chest X-rays (CXRs).METHODSWe performed independent RALE scoring by ≥2 reviewers on baseline CXRs from 425 inpatients with COVID-19 (discovery dataset), we recorded clinical variables and outcomes, and measured plasma host-response biomarkers and SARS-CoV-2 RNA load from subjects with available biospecimens.RESULTSWe found excellent inter-rater agreement for RALE scores (intraclass correlation co-efficient=0.93). The required level of respiratory support at the time of baseline CXRs (supplemental oxygen or non-invasive ventilation [n=178]; invasive-mechanical ventilation [n=234], extracorporeal membrane oxygenation [n=13]) was significantly associated with RALE scores (median [interquartile range]: 20.0[14.1-26.7], 26.0[20.5-34.0] and 44.5[34.5-48.0], respectively, pCONCLUSIONReproducible assessment of radiographic severity revealed significant associations with clinical and physiologic severity, host-response biomarkers and clinical outcome in COVID-19 pneumonia. Incorporation of radiographic severity assessments may provide prognostic and treatment allocation guidance in patients hospitalized with COVID-19. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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