Combined repeated-dose toxicity study of silver nanoparticles with the reproduction/developmental toxicity screening test
| Autor: | Moo Yeol Lee, Kyunghee Choi, Jeong-Sup Hong, Su-Hyon Kim, Junheon Yoon, Hyun-Mi Kim, Byung-Cheun Lee, Younghun Kim, Ig-Chun Eom, Eunhye Jo, Pilje Kim, Kwangsik Park, Sang Hee Lee, Jonghye Choi, Yeong-Rok Seo, Yeonjin Lee |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Silver Screening test media_common.quotation_subject Biomedical Engineering Developmental toxicity Metal Nanoparticles Pharmacology Biology Toxicology Silver nanoparticle Rats Sprague-Dawley Internal medicine Toxicity Tests medicine Animals Tissue Distribution Particle Size media_common Fetus Hematology Dose-Response Relationship Drug Reproduction Organ Size Rats Dose–response relationship Blood Toxicity Female |
| Zdroj: | Nanotoxicology. 8:349-362 |
| ISSN: | 1743-5404 1743-5390 |
| DOI: | 10.3109/17435390.2013.780108 |
| Popis: | Combined repeated-dose toxicity study of citrate-capped silver nanoparticles (7.9 ± 0.95 nm) with reproduction/developmental toxicity was investigated in rats orally treated with 62.5, 125 and 250 mg/kg, once a day for 42 days for males and up to 52 days for females. The test was performed based on the Organization for Economic Cooperation and Development test guideline 422 and Good Laboratory Practice principles. No death was observed in any of the groups. Alopecia, salivation and yellow discolouration of the lung were observed in a few rats but the symptoms were not dose-dependent. Haematology, serum biochemical investigation and histopathological analysis revealed no statistically significant differences between control group and the treated groups. Toxicity endpoints of reproduction/developmental screening test including mating, fertility, implantation, delivery and foetus were measured. There was no evidence of toxicity. |
| Databáze: | OpenAIRE |
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