Overt and occult hepatitis B infection after neonatal vaccination: mother-to-infant transmission and HBV vaccine effectiveness
| Autor: | Wei Fan, Anqun Hu, Miao Zhang, Haiyan Liu, Yingjie Zheng, Qian-ying Cai, Yijie Li, Wenhui Han, Qing Li, Tian-lei Wang, Yining He |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) Mother-to-infant transmission Hepatitis B virus Pediatrics medicine.medical_specialty 030106 microbiology Mothers Polymerase Chain Reaction Serology lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Pregnancy Prenatal Diagnosis Prevalence Humans Medicine Hepatitis B Vaccines lcsh:RC109-216 030212 general & internal medicine Phylogeny Hepatitis B Surface Antigens business.industry Transmission (medicine) Vaccination Infant Newborn Infant General Medicine Occult hepatitis B infection Viral Load Hepatitis B Occult Infectious Disease Transmission Vertical Infectious Diseases Immunization Cohort Female Occult hepatitis B virus infection business Viral load |
| Zdroj: | International Journal of Infectious Diseases, Vol 104, Iss, Pp 601-609 (2021) |
| ISSN: | 1201-9712 |
| Popis: | Objectives Overt and occult hepatitis B infection (HBI) among mothers and infants were investigated, and the effectiveness of vaccination against HBI was evaluated based on transmission types. Methods A hospital-based cohort was built with 2,734 mothers and 330 mother-infant pairs. Their demographic data were collected. Serological HBV markers, nested-PCR for HBV genes, viral load detection, and phylogenetic analysis were done. Results The overall prevalence of HBI among mothers was 12.1% (330/2,734), with 10.4% for the overt type and 1.8% for the occult type. In 330 out of 1,650 (20%) mother-infant pairs, the overall, type-I (from overt mother to overt infant), type-II (from overt mother to occult infant), and type-Ⅲ (from occult mother to occult infant) transmissions were 1.9% (1/54), 5.6% (3/54) and 0.0% (0/7). The refinement of HBI classification improved the estimate of vaccine effectiveness against HBI from 74.4%–80.9% to 94.4%, which was more prominent for type-II. One mother-infant pair with type-II transmission shared nearly identical complete sequences. However, the high rate of lost-to-follow-up could not be ignored. Conclusions During the transition period, HBV is mainly transmitted from the overt type of HBI mother to infant. Intensive prenatal screening for mothers is vital. |
| Databáze: | OpenAIRE |
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