Diffusion-weighted MRI abnormalities antedate the onset of sporadic Creutzfeldt-Jakob disease
| Autor: | Koichi Hirata, Akiko Kawasaki, Keisuke Suzuki, Takahide Nagashima |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty Progressive dementia Prodromal Symptoms Disease Electroencephalography Sensitivity and Specificity Creutzfeldt-Jakob Syndrome 03 medical and health sciences 0302 clinical medicine medicine Humans Aged medicine.diagnostic_test business.industry Sporadic Creutzfeldt-Jakob disease Hyperintensity 030104 developmental biology Diffusion Magnetic Resonance Imaging Disease Progression Neurology (clinical) medicine.symptom business Myoclonus 030217 neurology & neurosurgery Diffusion MRI Biomedical sciences |
| Zdroj: | Neurology. 87(8) |
| ISSN: | 1526-632X |
| Popis: | Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal progressive neurodegenerative disease that presents with progressive dementia and is accompanied by behavioral and psychiatric features and myoclonus. Multimodal approaches, such as EEG, diffusion-weighted imaging (DWI) of brain MRI, and CSF examinations, have been applied to increase the diagnostic accuracy of sCJD. Previous studies have suggested that DWI MRI could be the most useful modality for sCJD diagnosis.1–3 Recently, a study that compared MRI and pathologic findings demonstrated that DWI signal changes correlated with the disease duration and the histopathologic degree of spongiosis.4 However, when DWI signal changes emerge during the prodromal or incipient phase of sCJD remains unclear. Here, we present serial MRI findings acquired from a patient with sCJD before and after the onset of clinical symptoms, demonstrating that the emergence of unilateral cortical hyperintensity on DWI antedates the onset of sCJD. The authors thank Katsuya Satoh, MD, PhD, from the Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, and Tetsuyuki Kitamoto, MD, PhD, from the Division of CJD Science and Technology, Department of Prion Protein Research, Tohoku University Graduate School of Medicine, Miyagi, Japan, for the genetic analysis of this patient. |
| Databáze: | OpenAIRE |
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