Nonterminal differentiation represses the neoplastic phenotype in spontaneously and simian virus 40-transformed cells
| Autor: | Peter B. Maercklein, Parviz Minoo, Chin-Yuan Tzen, Robert E. Scott, David N. Estervig, Bryan J. Hoerl |
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| Rok vydání: | 1989 |
| Předmět: |
Cellular differentiation
Cell Simian virus 40 Biology medicine.disease_cause Cell Line Mice Antigen Transcription (biology) medicine Animals Cells Cultured Mice Inbred BALB C Multidisciplinary Cell Differentiation Transfection Virology Phenotype Cell biology Clone Cells medicine.anatomical_structure Cell Transformation Neoplastic Cell culture Carcinogenesis Research Article |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 86(5) |
| ISSN: | 0027-8424 |
| Popis: | The potential of nonterminal cellular differentiation to stably repress the expression of the neoplastic phenotype of transformed cells is established. Nonterminal differentiation induces spontaneously transformed 3T3 T cells to revert to a nontransformed state and induces the revertant cell clones to become resistant to retransformation by UV irradiation or 4-nitroquinoline oxide treatment. Nonterminal differentiation also induces simian virus 40-transformed 3T3 T cells to repress expression of the large tumor antigen and to revert to a nontransformed state. Although the molecular mechanisms that mediate these and other forms of anticancer activity have not been definitively established, data are presented which suggest that differentiation-induced repression of large tumor antigen expression can be regulated at the level of transcription and/or RNA processing. |
| Databáze: | OpenAIRE |
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