Retrospective Study of Adverse Reactions to Non Steroid Anti-Inflammatory Drugs (Nsaids): Predictive Value of Controlled Challe with Alternative Drugs
| Autor: | R. Di Corato, M. T. Ventura, G. Giuliano, M.G. Matino, L. Cenci, Alfredo Tursi |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Drug medicine.medical_specialty Adolescent media_common.quotation_subject Respiratory System Immunology Population Pharmacology Toxicology Oral administration Internal medicine medicine Humans Immunology and Allergy Child education Aged Retrospective Studies Skin media_common Asthma Aged 80 and over education.field_of_study business.industry Anti-Inflammatory Agents Non-Steroidal Respiratory disease Retrospective cohort study General Medicine Middle Aged medicine.disease digestive system diseases medicine.anatomical_structure Child Preschool Female business Follow-Up Studies Nimesulide medicine.drug Respiratory tract |
| Zdroj: | Immunopharmacology and Immunotoxicology. 21:455-468 |
| ISSN: | 1532-2513 0892-3973 |
| DOI: | 10.3109/08923979909007120 |
| Popis: | Acetylsalicylic acid (ASA) and NSAIDs, which inhibit the cyclo-oxygenase enzyme (C-O), are responsible, when administered at therapeutic doses, for adverse reactions mainly involving the skin and respiratory tract. The prevalence of intolerance to ASA and NSAIDs, assessed by the Section of Allergic and Immunological Diseases at the University of Bari on a population of 15,800 patients referred for allergic diseases over a period of 7 years, was found to be 11.4%. The adverse reactions to NSAIDs observed were in most cases skin complaints (88.9%), followed by respiratory symptoms (asthma +/- rhinitis, rhinitis) and general symptoms (shock, hypotension, lipothymia). The most common types of NSAIDs taken were pyrazolones, salicylics, arylpropionics, paracetamol. Controlled oral challenges with alternative NSAIDs (especially nimesulide) confirm the predictive power of this test: in fact, among patients who showed tolerance to the challenge drug, only 10.6% manifested unexpected reactions during the course of one year's follow-up. |
| Databáze: | OpenAIRE |
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