Onset of pulmonary Epstein–Barr virus‐positive diffuse large B‐cell lymphoma in a patient with silicosis

Autor: Koki Yamashita, Yuichi Fukuda, Saeko Jinnai, Midori Shimada, Ryosuke Ogata, Masataka Yoshida, Yasuhiro Tanaka, Takuya Hara, Hiroshi Mukae, Hiroaki Senju, Keisuke Iwasaki, Hiroshi Soda, Shota Nakashima, Hiroyuki Yamaguchi, Asuka Umemura
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Thoracic Cancer, Vol 13, Iss 1, Pp 133-136 (2022)
Thoracic Cancer
ISSN: 1759-7706
1759-7714
Popis: How Epstein–Barr virus (EBV)‐positive diffuse large B‐cell lymphoma (DLBCL) occasionally occurs following chronic inflammation remains to be elucidated. The case of a 57‐year‐old man who developed pulmonary EBV‐positive DLBCL from underlying silicosis lesions is presented. Immunohistochemical examination of the resected silicosis lesions showed predominant helper T cells and M1/M2 macrophages, with a lack of B cells, regulatory T cells, and resident memory T cells. Two years later, EBV‐positive DLBCL emerged unexpectedly from the silicosis. The imbalance of the immune cells in the microenvironment, at least in part, may help explain how chronic inflammation contributes to EBV‐positive DLBCL.
The underlying silicosis lesions showed predominant Th cells and M1/M2 macrophages, with a lack of B cells, Treg cells, and TRM cells. The imbalance of the immune cells in the microenvironment, at least in part, may help to explain how chronic inflammation contributes to EBV‐positive diffuse large B‐cell lymphoma.
Databáze: OpenAIRE
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