Polymorphisms in angiotensin-converting-enzyme gene and progression of IgA nephropathy

Autor:	P.N Harden, P.A Rowe, R.S.C Rodger, B.J.R Junor, J.D Briggs, A.G Jardine, C Geddes, M Boulton-Jones, J.H Mcllroy, J.M.C Connell
Rok vydání:	1995
Předmět:	Adult medicine.medical_specialty Genotype medicine.medical_treatment Molecular Sequence Data Blood Pressure Peptidyl-Dipeptidase A Nephropathy Polymorphism (computer science) Internal medicine Immunopathology medicine Humans Renal replacement therapy Allele Alleles DNA Primers Retrospective Studies Polymorphism Genetic Base Sequence biology Glomerulonephritis IGA Angiotensin-converting enzyme DNA General Medicine Middle Aged medicine.disease Introns Genotype frequency Endocrinology Creatinine biology.protein
Zdroj:	The Lancet. 345:1540-1542
ISSN:	0140-6736
DOI:	10.1016/s0140-6736(95)91088-3
Popis:	We have investigated the influence of the functional insertion (I) and deletion (D) polymorphism in intron 16 of the gene for angiotensin-converting enzyme (ACE) in a retrospective study of 100 patients with IgA nephropathy. There was no difference in genotype frequency compared with normal subjects. However, patients homozygous for the D allele tended to present at an earlier age (medians: DD, 33; ID, 34; II, 42 years) and to require renal replacement therapy at a younger age (medians 37, 42, and 48 years, respectively). The rate of progression was significantly worse in patients homozygous for the D allele. The DD genotype is associated with increased severity of disease in patients with IgA nephropathy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3a9386af0cc0b11049a7d6f33cbc8a https://doi.org/10.1016/s0140-6736(95)91088-3 Zobrazit plný text záznamu Plný text ve formátu HTML
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