Novel Metabolic Transformation Pathway for Cyclic Imides in Blastobacter sp. Strain A17p-4

Autor:	Chee Leong Soong, Jun Ogawa, Sakayu Shimizu, M. Honda
Rok vydání:	1996
Předmět:	chemistry.chemical_classification Cyclic compound food.ingredient Ecology Stereochemistry Glutarimide Applied Microbiology and Biotechnology Metabolic pathway chemistry.chemical_compound food Enzyme chemistry Succinimide Blastobacter Deamidation Imide Research Article Food Science Biotechnology
Zdroj:	Applied and Environmental Microbiology. 62:3814-3817
ISSN:	1098-5336 0099-2240
DOI:	10.1128/aem.62.10.3814-3817.1996
Popis:	The metabolic transformation pathway for cyclic imides in microorganisms was studied in Blastobacter sp. strain A17p-4. This novel pathway involves, in turn, hydrolytic ring opening of a cyclic imide to yield a monoamidated dicarboxylate, hydrolytic deamidation of the monoamidated dicarboxylate to yield a dicarboxylate, and dicarboxylate transformation similar to that in the tricarboxylic acid cycle. The initial step is catalyzed by a novel enzyme, imidase. Imidase and subsequent enzymes involved in this metabolic pathway are induced by some cyclic imides, such as succinimide and glutarimide. Induced cells metabolize various cyclic imides.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b390f1a96f86b9698b4b175512824c6 https://doi.org/10.1128/aem.62.10.3814-3817.1996 Zobrazit plný text záznamu