Predicting Stroke Outcomes Using Ankle-Brachial Index and Inter-Ankle Blood Pressure Difference

Autor: Young Dae Kim, Jimin Ha, Minho Han, Junghye Choi, Ji Hoe Heo, Hyo Suk Nam, Jin Kyo Choi, Eunjeong Park, Tae Jin Song, Jinkwon Kim
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Clinical Medicine
Volume 9
Issue 4
Journal of Clinical Medicine, Vol 9, Iss 1125, p 1125 (2020)
ISSN: 2077-0383
DOI: 10.3390/jcm9041125
Popis: Background: This study investigated the association of high ankle-brachial index difference (ABID) and systolic inter-ankle blood pressure difference (IAND) with short- and long-term outcomes in acute ischemic stroke patients without peripheral artery disease (PAD). Methods: Consecutive patients with acute ischemic stroke who underwent ankle-brachial index (ABI) measurement were enrolled. ABID was calculated as |right ABI-left ABI|. IAND and systolic inter-arm blood pressure difference (IAD) were calculated as |right systolic blood pressure &ndash
left systolic blood pressure|. Poor functional outcome was defined as modified Rankin Scale score &ge
3 at 3 months. Major adverse cardiovascular events (MACEs) were defined as stroke recurrence, myocardial infarction, or death. Results: A total of 2901 patients were enrolled and followed up for a median of 3.1 (interquartile range, 1.6&ndash
4.7) years. Among them, 2643 (84.9%) patients did not have PAD. In the logistic regression analysis, ABID &ge
0.15 and IAND &ge
15 mmHg were independently associated with poor functional outcome (odds ratio (OR), 1.970, 95% confidence interval (CI), 1.175‒3.302
OR, 1.665, 95% CI, 1.188‒2.334, respectively). In Cox regression analysis, ABID &ge
15 mmHg were independently associated with MACEs (hazard ratio (HR), 1.514, 95% CI, 1.058‒2.166
HR, 1.343, 95% CI, 1.051‒1.716, respectively) and all-cause mortality (HR, 1.524, 95% CI, 1.039‒2.235
HR, 1.516, 95% CI, 1.164‒1.973, respectively) in patients without PAD. Conclusion: High ABID and IAND are associated with poor short-term outcomes, long-term MACE occurrence, and all-cause mortality in acute ischemic stroke without PAD.
Databáze: OpenAIRE
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