Erb, an allele to Era, and evidence for a third allele, Er
| Autor: | M B Hartrick, Janis R. Hamilton, K M Beattie, R H Walker |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Erythrocytes media_common.quotation_subject Immunology Cell Antigen Pregnancy medicine Humans Immunology and Allergy Allele Allele frequency Gene Alleles media_common Daughter biology Hemagglutination Tests Hematology Molecular biology Pedigree White (mutation) medicine.anatomical_structure Blood Group Antigens biology.protein Female Antibody |
| Zdroj: | Transfusion. 28:268-271 |
| ISSN: | 1537-2995 0041-1132 |
| Popis: | An antibody against a low-incidence antigen was detected in the serum of a woman whose newborn infant was found to have a positive direct antiglobulin test. The antibody failed to agglutinate 79 examples of red cells having low-incidence antigens and 16 examples of high-incidence antigen-negative red cells. The woman's serum reacted strongly with her husband's red cells in the antiglobulin test and with 5 of 6 Er(a-) cell samples from unrelated donors, suggesting that the antigen has an antithetical relationship to Era. The failure of the serum to react with one Er(a-) cell sample and with cells from the Er(a+) daughter of an Er(a-b+) mother gives evidence for a silent allele, Er. Four Er(b+) bloods were found among 605 random white donors, indicating a gene frequency for Erb of 0.0033. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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