A case of clonally distinct relapse of Burkitt lymphoma 9 years after complete remission
| Autor: | Kosuke Tsuboi, Naoya Nakamura, Miharu Yabe, Tomoki Kikuchi, Minoru Kojima, Yoshiaki Ogawa, Yara Yukie Kikuti, Kiyoshi Ando, Hiromichi Murayama, Mami Tokunaka, Makiko Moriuchi |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Oncology medicine.medical_specialty Adolescent medicine.medical_treatment Molecular Sequence Data Hematopoietic stem cell transplantation Biology Dexamethasone Autologous stem-cell transplantation Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Ifosfamide Cyclophosphamide Etoposide Chemotherapy Hematology Base Sequence Genes Immunoglobulin Remission Induction Cytarabine Hematopoietic Stem Cell Transplantation medicine.disease Burkitt Lymphoma V(D)J Recombination Lymphoma Transplantation Regimen Methotrexate Doxorubicin Vincristine Immunology Neoplasm Recurrence Local Immunoglobulin Heavy Chains medicine.drug |
| Zdroj: | International Journal of Hematology. 101:520-524 |
| ISSN: | 1865-3774 0925-5710 |
| DOI: | 10.1007/s12185-014-1729-1 |
| Popis: | We report a case of HIV-negative Burkitt lymphoma (BL) that relapsed 9 years after complete remission. We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to be clonally distinct. The patient received the R-Hyper CVAD/R-MA regimen; however, leukoencephalopathy subsequently developed due to the effect of cytarabine, and the regimen was changed to R-IVAM. The patient achieved complete remission and received high-dose chemotherapy following autologous stem cell transplantation. He maintained the complete remission for 72 months after transplantation. Given this outcome, we suggest that clonally distinct relapse of HIV-negative BL may exhibit a good prognosis. |
| Databáze: | OpenAIRE |
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