The Emerging Role of MicroRNAs in Bone Diseases and Their Therapeutic Potential
| Autor: | Luis Alberto Bravo Vázquez, Mariana Yunuen Moreno Becerril, Erick Octavio Mora Hernández, Gabriela García de León Carmona, María Emilia Aguirre Padilla, Samik Chakraborty, Anindya Bandyopadhyay, Sujay Paul |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Pharmaceutical Science
Organic chemistry Review Exosomes RNA Transport Analytical Chemistry QD241-441 Osteogenesis Drug Discovery therapeutics Animals Humans metastasis Neoplasm Metastasis Physical and Theoretical Chemistry Osteosarcoma Osteonecrosis Disease Management microRNAs bone diseases Gene Expression Regulation Chemistry (miscellaneous) Osteoporosis Molecular Medicine biomarker RNA Interference Disease Susceptibility gene regulation Biomarkers Signal Transduction |
| Zdroj: | Molecules, Vol 27, Iss 211, p 211 (2022) Molecules |
| ISSN: | 1420-3049 |
| Popis: | MicroRNAs (miRNAs) are a class of small (20–24 nucleotides), highly conserved, non-coding RNA molecules whose main function is the post-transcriptional regulation of gene expression through sequence-specific manners, such as mRNA degradation or translational repression. Since these key regulatory molecules are implicated in several biological processes, their altered expression affects the preservation of cellular homeostasis and leads to the development of a wide range of pathologies. Over the last few years, relevant investigations have elucidated that miRNAs participate in different stages of bone growth and development. Moreover, the abnormal expression of these RNA molecules in bone cells and tissues has been significantly associated with the progression of numerous bone diseases, including osteoporosis, osteosarcoma, osteonecrosis and bone metastasis, among others. In fact, miRNAs regulate multiple pathological mechanisms, including altering either osteogenic or osteoblast differentiation, metastasis, osteosarcoma cell proliferation, and bone loss. Therefore, in this present review, aiming to impulse the research arena of the biological implications of miRNA transcriptome in bone diseases and to explore their potentiality as a theragnostic target, we summarize the recent findings associated with the clinical significance of miRNAs in these ailments. |
| Databáze: | OpenAIRE |
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