Aspirin alone and combined with a statin suppresses eicosanoid formation in human colon tissue[S]
| Autor: | Nils Helge Schebb, Heike Gottschall, Dirk Hartmann, Nadine Rohwer, Annika I. Ostermann, Katharina M. Rund, Fabian Nolte, Christoph Schmöcker, Karsten H. Weylandt, Laura Kutzner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Statin medicine.drug_class Colorectal cancer Colon colorectal cancer QD415-436 Pharmacology Biochemistry Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology arachidonic acid medicine Humans Aged Aspirin biology business.industry Cell Biology Lipid signaling Colonoscopy acetylsalicylic acid medicine.disease digestive system diseases cyclooxygenase 030104 developmental biology Thromboxanes chemistry Eicosanoid 030220 oncology & carcinogenesis biology.protein lipidomics Eicosanoids Arachidonic acid lipids (amino acids peptides and proteins) Female Cyclooxygenase Hydroxymethylglutaryl-CoA Reductase Inhibitors business Patient-Oriented and Epidemiological Research medicine.drug |
| Zdroj: | Journal of Lipid Research, Vol 59, Iss 5, Pp 864-871 (2018) |
| Popis: | Eicosanoids, including prostaglandins (PGs) and thromboxanes, are broadly bioactive lipid mediators and increase colon tumorigenesis possibly through chronic inflammatory mechanisms. Epidemiological and experimental data suggest that acetylsalicylic acid (ASA) helps prevent colorectal cancer (CRC), possibly through cyclooxygenase (COX)-mediated suppression of eicosanoid, particularly PGE(2), formation. Recent studies suggest that statins prevent CRC and improve survival after diagnosis. We identified patients on ASA and/or statin treatment undergoing routine colonoscopy and measured eicosanoid levels in colonic mucosa with targeted metabolomics technology (LC-MS/MS). ASA-treated individuals (n = 27) had significantly lower tissue eicosanoid levels of most COX-derived metabolites than untreated individuals (n = 31). In contrast, COX-derived lipid metabolites tended to be higher in patients with statin treatment (n = 7) as compared with those not receiving statins (n = 24). This effect was not discernible in subjects treated with ASA and statins (n = 11): Individuals treated with both drugs showed a pronounced suppression of COX-derived eicosanoids in colon tissue, even compared with subjects treated with ASA alone. Our data from a routine clinical setting support the hypothesis that ASA and statins could inhibit CRC development via lipid mediator modification. Further studies should directly investigate the effect of dual ASA and statin treatment on colon tumorigenesis in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|