A prospective observational study on the stress levels at the time of embryo transfer and pregnancy testing following in vitro fertilisation treatment: a comparison between women with different treatment outcomes
| Autor: | Chi Chiu Wang, Tya Chan, Sotirios H. Saravelos, PW Chung, Daljit Singh Sahota, Cwc Cheung, Tin-Chiu Li |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy Rate Pregnancy Tests Visual analogue scale medicine.medical_treatment Population Perceived Stress Scale Fertilization in Vitro Intracytoplasmic sperm injection Miscarriage 03 medical and health sciences 0302 clinical medicine Pregnancy Stress Physiological medicine Humans Prospective Studies education Psychiatric Status Rating Scales education.field_of_study 030219 obstetrics & reproductive medicine In vitro fertilisation Obstetrics business.industry Beck Depression Inventory Obstetrics and Gynecology Embryo Transfer medicine.disease Embryo transfer Abortion Spontaneous Treatment Outcome Salivary alpha-Amylases Female business Infertility Female Biomarkers Stress Psychological |
| Zdroj: | BJOG: An International Journal of Obstetrics & Gynaecology. 126:271-279 |
| ISSN: | 1471-0528 1470-0328 |
| Popis: | OBJECTIVE To ascertain whether stress biomarkers and psychological indices of stress may predict both conception and miscarriage rates in women undergoing in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI). DESIGN Prospective observational study. SETTING A university-affiliated tertiary hospital. POPULATION Infertile women who were undergoing fresh or frozen IVF/ICSI cycles. METHODS Women were recruited to (1) complete validated psychological questionnaires (visual analogue scale of stress, state-trait anxiety inventory, perceived stress scale, fertility problem inventory, Beck depression inventory, and general health questionnaire), at the time of embryo transfer (ET) and pregnancy testing (PT), and (2) provide saliva samples for α-amylase (sAA) measurement before and after ET and at PT. MAIN OUTCOME MEASURES Women were grouped according to subsequent reproductive outcome; scores/levels of all tests were then compared between groups at each time-point. RESULTS In all, 197 women completed the study, of which 92 conceived and 28 miscarried. The level of psychological stress, as measured by questionnaires, was highest at the time of PT, whereas the level of biological stress as measured by sAA level (IU/l) post-ET (1.8 × 105 ± 1.5 × 105 ) was significantly (P |
| Databáze: | OpenAIRE |
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