Associations of Human Papillomavirus (HPV) genotypes with high-grade cervical neoplasia (CIN2+) in a cohort of women living with HIV in Burkina Faso and South Africa
| Autor: | Bernard Sawadogo, Clare Gilham, Helen A. Weiss, Nicolas Meda, Philippe Mayaud, Michel Segondy, Tanvier Omar, Admire Chikandiwa, Sinead Delany-Moretlwe, Helen Kelly, Olga Lompo, Jean Ngou, Sylviane Doutre |
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| Přispěvatelé: | Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )-Université de Montpellier (UM), Université Joseph Ki-Zerbo [Ouagadougou] (UJZK), University of the Witwatersrand [Johannesburg] (WITS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
RNA viruses
Viral Diseases Biopsy Human immunodeficiency virus (HIV) Uterine Cervical Neoplasms HIV Infections Cervix Uteri Pathology and Laboratory Medicine medicine.disease_cause South Africa 0302 clinical medicine Immunodeficiency Viruses [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Genotype Medicine and Health Sciences Prevalence Outpatient clinic Prospective Studies 030212 general & internal medicine Prospective cohort study Papillomaviridae Vaccines Multidisciplinary Obstetrics virus diseases female genital diseases and pregnancy complications 3. Good health Infectious Diseases Medical Microbiology Viral Pathogens 030220 oncology & carcinogenesis Viruses Cohort Medicine Female Pathogens Anatomy Research Article Adult Human Papillomavirus Infection Genotyping medicine.medical_specialty Histology Infectious Disease Control Papillomaviruses Urology Science Sexually Transmitted Diseases Surgical and Invasive Medical Procedures [SDV.CAN]Life Sciences [q-bio]/Cancer HPV vaccines [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics Research and Analysis Methods Cervical intraepithelial neoplasia Microbiology HPV-16 03 medical and health sciences Retroviruses Burkina Faso medicine Humans Papillomavirus Vaccines Molecular Biology Techniques Microbial Pathogens Molecular Biology Gynecology Genitourinary Infections business.industry Lentivirus Papillomavirus Infections Organisms Biology and Life Sciences HIV Human Papillomavirus medicine.disease [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie DNA viruses business |
| Zdroj: | PLoS ONE, Vol 12, Iss 3, p e0174117 (2017) PLoS ONE PLoS ONE, Public Library of Science, 2017, 12 (3), pp.e0174117. ⟨10.1371/journal.pone.0174117⟩ |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0174117⟩ |
| Popis: | ObjectiveTo describe associations of high-risk human papillomavirus (HR-HPV) with high-grade cervical intraepithelial neoplasia (CIN2+) in women living with HIV (WLHIV) in Burkina Faso (BF) and South Africa (SA).MethodsProspective cohort of WLHIV attending HIV outpatient clinics and treatment centres. Recruitment was stratified by ART status. Cervical HPV genotyping using INNO-LiPA and histological assessment of 4-quadrant cervical biopsies at enrolment and 16 months later.ResultsAmong women with CIN2+ at baseline, the prevalence of any HR-HPV genotypes included in the bi/quadrivalent (HPV16/18) or nonavalent (HPV16/18/31/35/45/52/58) HPV vaccines ranged from 37% to 90%. HPV58 was most strongly associated with CIN2+ (aOR = 5.40, 95%CI: 2.77-10.53). At 16-months follow-up, persistence of any HR-HPV was strongly associated with incident CIN2+ (aOR = 7.90, 95%CI: 3.11-20.07), as was persistence of HPV16/18 (aOR = 5.25, 95%CI: 2.14-12.91) and the additional HR types in the nonavalent vaccine (aOR = 3.23, 95%CI: 1.23-8.54).ConclusionHR-HPV persistence is very common among African WLHIV and is linked to incident CIN2+. HPV vaccines could prevent between 37-90% of CIN2+ among African WLHIV. |
| Databáze: | OpenAIRE |
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