Characterization of the Neutralizing Antibody Response in a Case of Genetically Linked HIV Superinfection
| Autor: | Daniel C. Douek, Janet Seeley, Nicole A. Doria-Rose, Stephen F. Porcella, Andrew F. Longosz, Billy N. Mayanja, Andrew D. Redd, Andrea R Shiakolas, Anatoli Kamali, Michael P Walker, Amy Ransier, Daniel Bruno, Gershim Asiki, Pontiano Kaleebu, Thomas C. Quinn, Deogratius Ssemwanga, Samuel Darko, Craig Martens, John R. Mascola, Rebecca N. Nsubuga |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine viruses Heterologous HIV Infections HIV superinfection HIV Antibodies medicine.disease_cause Virus Major Articles and Brief Reports 03 medical and health sciences Neutralization Tests parasitic diseases medicine Homologous chromosome Humans Immunology and Allergy Heterosexuality Neutralizing antibody biology Strain (biology) virus diseases biochemical phenomena metabolism and nutrition Antibodies Neutralizing Virology 030104 developmental biology Infectious Diseases Superinfection Antibody Formation HIV-1 biology.protein Female Antibody |
| Zdroj: | The Journal of Infectious Diseases. 217:1530-1534 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | This report describes the identification of a genetically confirmed linked heterosexual human immunodeficiency virus (HIV) superinfection (HIV-SI) in a woman with chronic HIV infection who acquired a second strain of the virus from her husband. Serum neutralizing antibody (NAb) responses against their homologous and heterologous viruses, including the superinfecting strain, in the woman and her husband were examined before and after onset of HIV-SI. The woman displayed a moderately potent and broad anti-HIV NAb response prior to superinfection but did not possess NAb activity against the superinfecting strain. This case highlights the unique potential of linked HIV-SI studies to examine natural protection from HIV infection. |
| Databáze: | OpenAIRE |
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