'Dose-Dense Primary Chemotherapy, as Part of Multidisciplinary Treatment, for Inoperable Stage III B Breast Cancer - Long-Term Results of a Phase II Trial'
| Autor: | Antonio Contu, Francesco Atzori, Antonio Farris, Antioco Scanu, Anna Maria Catino, Sergio Palmeri, Maria Teresa Ionta, Luigi Minerba, Bruno Massidda |
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| Přispěvatelé: | MASSIDDA B, ATZORI F, SCANU A, CONTU A, FARRIS A, CATINO AM, PALMERI S, MINERBA L, IONTA MT |
| Rok vydání: | 2007 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Dose-dense chemotherapy medicine.medical_treatment Breast Neoplasms Mastectomy Segmental Breast cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Stage (cooking) Etoposide Mastectomy Epirubicin Chemotherapy business.industry Cancer General Medicine Middle Aged medicine.disease Combined Modality Therapy Surgery Treatment Outcome Female Cisplatin business medicine.drug Follow-Up Studies |
| Popis: | Background: Primary chemotherapy as part of multidisciplinary approach is the established treatment for inoperable stage III B breast cancer. The primary endpoints were conversion to operable disease and feasibility of conservative surgery (breast-conserving therapy: BCT); secondary were clinical and pathological complete response rate, local and distant control and safety of the primary regimen. Methods: Between 1998 and 2001, 40 inoperable breast cancer patients ≤60 years, 72% T4abc and 28% T4d, received 6 cycles of primary PEV dose-dense regimen: cisplatin 50 mg/m2, epirubicin 100 mg/m2 and vinorelbine 25 mg/m2, i.v. (q 14). Modified radical mastectomy (MRM) or BCT was performed, followed by adjuvant chemotherapy, radiotherapy and hormone therapy. Results: All patients were converted to operable disease, and BCT was feasible in 24% of T4abc patients. After a median follow-up of 84 months (range 58–96), local and distant relapses were 7.5% (0% in BCT ) and 25% (25% in BCT), respectively. Clinical response was 80% (clinical complete response [cCR]: 20%); pathological complete response (pCR) was 40% in breast, 50% in axilla (pLN0); 32% both in breast and axilla. Neutropenia (G4, 30%), leukopenia (G4, 25%), alopecia (G2, 100%), nausea and vomiting (G4, 20%) were the most common toxicities. Conclusions: The PEV dose-dense regimen seems to be highly effective in terms of resectability and pCR. Toxicity, mainly hematological, was acceptable. Successful BCT is feasible, in selected patients, without compromising local and distant control. |
| Databáze: | OpenAIRE |
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