Basic fibroblast growth factor in asthma: Measurement in bronchoalveolar lavage fluid basally and following allergen challenge
| Autor: | Anthony E. Redington, Anthony J. Frew, Ratko Djukanovic, Stephen T. Holgate, J. Madden, William R. Roche, Peter H. Howarth |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Allergy Angiogenesis Immunology Basic fibroblast growth factor Bronchial Provocation Tests Muscle hypertrophy Leukocyte Count chemistry.chemical_compound Forced Expiratory Volume Humans Immunology and Allergy Medicine Asthma medicine.diagnostic_test business.industry Respiratory disease respiratory system medicine.disease respiratory tract diseases Bronchoalveolar lavage medicine.anatomical_structure chemistry Female Fibroblast Growth Factor 2 business Bronchoalveolar Lavage Fluid Respiratory tract |
| Zdroj: | Journal of Allergy and Clinical Immunology. 107:384-387 |
| ISSN: | 0091-6749 |
| DOI: | 10.1067/mai.2001.112268 |
| Popis: | Airway remodeling in asthma refers to a collection of chronic structural changes including subepithelial fibrosis, airway smooth muscle hypertrophy/hyperplasia, and possibly angiogenesis. The mechanisms leading to remodeling are not well defined. One molecule of possible relevance is basic fibroblast growth factor (bFGF), which is a potent mitogen for fibro-blasts, airway smooth muscle cells, and endothelial cells. To test the hypothesis that bFGF expression is increased in asthma, we measured levels of the growth factor in bronchoalveolar lavage (BAL) fluid. Basally, BAL fluid bFGF concentrations were significantly higher in subjects with atopic asthma than in control subjects without asthma (median 0.22 vs 0.06 pg/mL, P = .003). The effect of acute allergen exposure was examined with a segmental bronchoprovocation model in a separate group of subjects with atopic asthma. Ten minutes after segmental bronchoprovocation there was a 5-fold increase in bFGF levels in BAL fluid recovered from allergen-challenged sites compared with control saline-challenged sites (1.52 vs 0.30 pg/mL, P < .002). We conclude that basal levels of BAL fluid bFGF are increased in atopic asthma and that a further increase occurs in response to acute allergen exposure. These findings lend support to the hypothesis that bFGF is implicated in airway remodeling in asthma. |
| Databáze: | OpenAIRE |
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