The prognostic value of myocardial deformational patterns on all-cause mortality is modified by ischemic cardiomyopathy in patients with heart failure
| Autor: | Philip Brainin, Morten Schou, Tor Biering-Sørensen, Peter Godsk Jørgensen, Anna Engell Holm, Thomas Fritz-Hansen, Niels Eske Bruun, Sune Pedersen, Morten Sengeløv |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Ischemia Speckle tracking echocardiography Heart failure 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Interquartile range Predictive Value of Tests Internal medicine medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Systole Mortality Heart Failure Ischemic cardiomyopathy Ejection fraction Postsystolic shortening Proportional hazards model business.industry Stroke Volume Early systolic lengthening medicine.disease Prognosis Deformation Cardiology Cardiology and Cardiovascular Medicine business Cardiomyopathies |
| Zdroj: | Brainin, P, Holm, A E, Sengeløv, M, Jørgensen, P G, Bruun, N E, Schou, M, Pedersen, S, Fritz-Hansen, T & Biering-Sørensen, T 2021, ' The prognostic value of myocardial deformational patterns on all-cause mortality is modified by ischemic cardiomyopathy in patients with heart failure ', International Journal of Cardiovascular Imaging, vol. 37, no. 11, pp. 3137-3144 . https://doi.org/10.1007/s10554-021-02291-3 |
| ISSN: | 1875-8312 |
| Popis: | Early systolic lengthening and postsystolic shortening may yield prognostic information in cardiovascular high-risk groups. We aimed to investigate the prognostic potential of these patterns in patients with heart failure with reduced ejection fraction (HFrEF), and specifically if the value was greater in patients with ischemic etiology. A total of 884 patients with HFrEF (66 ± 12 years, male 73%, mean EF 28 ± 9%) underwent speckle tracking echocardiography. Of these, 61% suffered from ischemic cardiomyopathy (ICM). Patients were followed for all-cause mortality. We assessed myocardial lengthening during early systole, defined by the early systolic strain index (ESI): [-100x (peak positive strain/maximal strain)] and myocardial shortening after aortic valve closure, defined by the postsystolic strain index (PSI): [100x (postsystolic strain-peak systolic strain)/maximal strain]. During median follow-up of 3.4 [interquartile range 1.9 to 4.8] years, 132 patients (15%) died. ICM modified the relationship between ESI and all-cause mortality (P interaction = 0.008), but not for PSI (P interaction = 0.13). When assessing patients with ICM by Cox proportional hazards models, per 1% increase in ESI (HR 1.09 [1.04 to 1.15], P |
| Databáze: | OpenAIRE |
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