Long term beta-1 adrenergic blockade restores adrenomedullary activity in primary hypertension
| Autor: | Cees J. Tack, Theo Thien, Jacques J. Willemsen, Paul Smits, Marie-Cecile Jacobs, Jacques W.M. Lenders |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Epinephrine Adrenergic receptor algemeen [Geneeskunde] Adrenergic beta-Antagonists Ontwikkeling van methodes voor het meten van hormonen in lichaamsvloeistoffen Effecten en lotgevallen van geneesmiddelen in nier en bloedvaten Medical sciences Medische Wetenschappen Norepinephrine (medication) Norepinephrine Clinical The sympathoadrenal system and primary hypertension Internal medicine medicine Humans Bescherming en bevordering van de menselijke gezondheid Het sympathoadrenale systeem en primaire hypertensie GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) Development of assays for measurements of hormones in body fluids Pharmacology Epinephrine secretion business.industry Hemodynamics Gezondheid Geneeskunde: algemeen Atenolol Financial Economics medicine.anatomical_structure Blood pressure Endocrinology Hypertension Pharmacology Clinical Vascular resistance Catecholamine Female Cardiology and Cardiovascular Medicine business Effects and kinetics of drugs in kidney and blood vessels medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology, 30, 338-342 Journal of Cardiovascular Pharmacology, 30, pp. 338-342 Journal of Cardiovascular Pharmacology, 30, 3, pp. 338-342 |
| ISSN: | 0160-2446 |
| Popis: | Summary: in this; study we examined the effects of long-term treatment of 19 patients with primary hypertension with the sr adrenoceptor antagonist atenolol on norepinephrine and epi nephrine kinetics, at rest and during sympathoadrenal stimula tion by lower body negative pressure. Norepinephrine and epinephrine kinetics were measured by using the radioisotopedi luti on technique by steady-state infusion of tritiated norepi nephrine and epinephrine. The patients were studied before and at the end of 3 months of treatment with atenolol (50 or 100 mg daily). A control group of four normotensive subjects was stud ied before and after 3 months without any drug treatment. In this group, only arterial blood samples were collected without infu sion of the tritiated catecholamines. Atenolol decreased blood pressure and heart rate, but forearm vascular resistance was not affected by atenolol. During atenolol, baseline arterial plasma epinephrine decreased from 0.23 ± O.02 to U.17 ± O.Oi nM (p < 0,05), and this was accompanied by a decrease in total body ep inephrine spillover from 0,50 ± 0.05 to 0.35 ± 0.04 nmol/min (p < 0.05), In the control group, arterial plasma epinephrine had not decreased after 3 months. In addition, the increment of arterial plasma epinephrine during lower body negative pressure at-40 mm Hg was attenuated during atenolol. Atenolol had no effect on total body and forearm norepinephrine spillover rates, either at rest or during lower body negative pressure. Clearance ivtes of epinephrine and norepinephrine were not significantly ef fected by atenolol. These results suggest that treatment of pa tients with primary hypertension with the s j-adrenoceptor blocker atenolol inhibits the adrenomedullary secretion of epi nephrine, but it does not affect the biochemical indices of sympathoneural activity, It remains speculative whether this selec tive effect of atenolol on epinephrine secretion contributes to its hypotensive action and to its cardioprotective effects in the long term. KeyWords: s (-Adrenergic— Sympathoadrenal activity— Hypertension— Catecholamines. |
| Databáze: | OpenAIRE |
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