Helicobacter pylori has no effect on plasma ghrelin levels
| Autor: | Adnan Gokcel, Akatlı Kursad Ozsahin, Birol Özer, Ender Serin, Yüksel Gümürdülü, Nilgün Güvener, Fazilet Kayaselçuk |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
medicine.medical_specialty Biopsy Peptide Hormones Endocrinology Diabetes and Metabolism Spirillaceae Body Mass Index Helicobacter Infections Immunoenzyme Techniques Endocrinology Internal medicine Gastroscopy Blood plasma medicine Humans Prospective Studies Antrum Gastrin Helicobacter pylori biology Stomach digestive oral and skin physiology General Medicine Middle Aged biology.organism_classification Lipids Ghrelin medicine.anatomical_structure Female Gastritis medicine.symptom |
| Zdroj: | European Journal of Endocrinology. :423-426 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/eje.0.1480423 |
| Popis: | OBJECTIVE: Helicobacter pylori is the major etiologic agent for chronic active gastritis, and it also plays a crucial role in gastric and duodenal ulcer disease, as well as in gastric carcinoma. H. pylori infection has been shown to decrease plasma somatostatin (SST) and increase plasma gastrin concentrations. Ghrelin is a recently discovered peptide produced mostly in the stomach of rodents and humans and is secreted into the bloodstream. There is no data in the literature about the relationship between H. pylori and ghrelin. DESIGN: Thirty-nine age- and BMI-matched H. pylori infection positive and negative women, from whom biopsy specimens were taken during gastric endoscopy, were included in the study. METHODS: Total ghrelin was measured by enzyme immunoassay (EIA) in Medistek. All samples were measured in duplicate and averaged; results differing by more than 20% were re-assayed. Two biopsy specimens from antrum, corpus and fundus were obtained. RESULTS: Fifteen of the subjects were H. pylori negative and 24 were H. pylori positive. Age, BMI, lipid profile and insulin sensitivity indices of the groups were similar. Plasma ghrelin levels (375.92+/-7.10 vs 370.00+/-4.14 pmol/l; P>0.05) of H. pylori negative and positive groups did not differ significantly. CONCLUSION: H. pylori has no effect on plasma ghrelin concentration. |
| Databáze: | OpenAIRE |
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