Circulating membrane-derived microvesicles in redox biology

Autor: Michael C. Larson, Cheryl A. Hillery, Neil Hogg
Rok vydání: 2014
Předmět:
Redox signaling
Neutrophils
Angiogenesis
Free radicals
Medical Biochemistry and Metabolomics
Matrix metalloproteinase
medicine.disease_cause
Biochemistry
Muscle
Smooth
Vascular
Cell membrane
Cell-Derived Microparticles
Neoplasms
Pathology
Lymphocytes
Phospholipids
Cancer
chemistry.chemical_classification
Neovascularization
Pathologic
medicine.diagnostic_test
Cell biology
medicine.anatomical_structure
Muscle
Smooth
Oxidation-Reduction
Microvesicles
Blood Platelets
Biochemistry & Molecular Biology
Cell signaling
1.1 Normal biological development and functioning
Microparticles
Biology
Article
Flow cytometry
Medicinal and Biomolecular Chemistry
Underpinning research
Vascular
Physiology (medical)
medicine
Animals
Humans
Neovascularization
Pathologic
Reactive oxygen species
Macrophages
Cell Membrane
Endothelial Cells
Matrix Metalloproteinases
Oxidative Stress
chemistry
Biochemistry and Cell Biology
Oxidative stress
Zdroj: Free Radical Biology and Medicine. 73:214-228
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2014.04.017
Popis: Microparticles or microvesicles (MVs) are subcellular membrane blebs shed from all cells in response to various stimuli. MVs carry a battery of signaling molecules, many of them related to redox-regulated processes. The role of MVs, either as a cause or as a result of cellular redox signaling, has been increasingly recognized over the past decade. This is in part due to advances in flow cytometry and its detection of MVs. Notably, recent studies have shown that circulating MVs from platelets and endothelial cells drive reactive species-dependent angiogenesis; circulating MVs in cancer alter the microenvironment and enhance invasion through horizontal transfer of mutated proteins and nucleic acids and harbor redox-regulated matrix metalloproteinases and procoagulative surface molecules; and circulating MVs from red blood cells and other cells modulate cell-cell interactions through scavenging or production of nitric oxide and other free radicals. Although our recognition of MVs in redox-related processes is growing, especially in the vascular biology field, much remains unknown regarding the various biologic and pathologic functions of MVs. Like reactive oxygen and nitrogen species, MVs were originally believed to have a solely pathological role in biology. And like our understanding of reactive species, it is now clear that MVs also play an important role in normal growth, development, and homeostasis. We are just beginning to understand how MVs are involved in various biological processes-developmental, homeostatic, and pathological-and the role of MVs in redox signaling is a rich and exciting area of investigation.
Databáze: OpenAIRE
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