Effect of feeding Acacia abyssinica and of its extracts given by different routes on rats
| Autor: | M. A. Salad, S. E. I. Adam, K. N. AL-Redhaiman |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Ethyl acetate Acacia Weight Gain chemistry.chemical_compound Eating Medicine Animals Rats Wistar Leukopenia biology Traditional medicine business.industry Plant Extracts Albumin General Medicine biology.organism_classification Acacia abyssinica Blood Cell Count Diet Rats Kidney Tubules Complementary and alternative medicine chemistry Toxicity Urea Plant Bark Solvents medicine.symptom Powders business Weight gain Blood Chemical Analysis |
| Zdroj: | The American journal of Chinese medicine. 31(2) |
| ISSN: | 0192-415X |
| Popis: | The effect of a diet consisting of 2% and 10% of Acacia abyssinica bark on Wistar rats treated for 6 weeks was examined. A 2% A. abyssinica diet was not toxic to rats. Impairment of growth and hepatonephropathy were observed in rats on a 10% A. abyssinica diet. By whatever route it was administered, either intraperitoneally (i.p.) or orally (p.o.), the ethyl acetate extract in daily doses of 500 mg/kg body weight was the most toxic and lethal to rats and caused hepatonephropathy, widespread hemorrhage and congestion and fibrinous peritonitis following i.p. administration. The aqueous and ethanol extracts in similar doses to ethyl acetate extract were only lethal to rats when given via the i.p. route. Lesions were accompanied by anemia, leukopenia and alterations in serum AST activity and concentrations of urea, total protein and albumin. |
| Databáze: | OpenAIRE |
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