Effects of chronic low-dose exposure of rat fetuses to methylmercury hydroxide
| Autor: | Mottet Nk |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Embryology
medicine.medical_specialty Necrosis Offspring Health Toxicology and Mutagenesis Toxicology Lacrimal apparatus Salivary Glands chemistry.chemical_compound Fetus Pregnancy Internal medicine medicine Animals Methylmercury Fetal Death Maternal-Fetal Exchange Swimming Behavior Animal Dose-Response Relationship Drug business.industry Lacrimal Apparatus Abnormalities Drug-Induced Brain Feeding Behavior Mercury Methylmercury Compounds medicine.disease Grooming Resorption Rats Fetal Diseases medicine.anatomical_structure Endocrinology chemistry Animals Newborn Liver Auditory Perception Maternal death Female medicine.symptom business Locomotion Developmental Biology |
| Zdroj: | Teratology. 10(2) |
| ISSN: | 0040-3709 |
| Popis: | Near-term fetal rats were examined for possible pathological changes produced by multiple low-dose subcutaneous injections of methylmercury hydroxide during pregnancy. The near-term maternal liver content of mercury served as an index of body content. At liver contents below 15 μg/g maternal and fetal mortality and fetal size were unaffected. The threshold of effect occurred at 15 μg/g maternal liver. From the threshold level to 75 μg/g (maternal toxic level) there was generally a dose-response relation characterized by increasing maternal death, prenatal resorption, and fetal death, and decreasing fetal weight. Generalized fetal edema occurred at the maternal toxic dose level. No gross or microscopic malformations were found in the fetuses. Electron microscopy of samples of near-term fetal lacrimal, submandibular, and parotid glands revealed no ultrastructural changes or necrosis. The development of behavioral characteristics in offspring of rats exposed to comparable levels of methylmercury was similar to the controls throughout 21 days of observation. |
| Databáze: | OpenAIRE |
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