Orientation and flexibility of the choline head group in phosphatidylcholine bilayers
| Autor: | Hans-Ulrich Gally, Roland Wohlgemuth, Joachim Seelig |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Magnetic Resonance Spectroscopy
Flexibility (anatomy) Phosphorylcholine Chemistry Stereochemistry Neutron diffraction Molecular Conformation Biophysics Membranes Artificial Cell Biology Glycerylphosphorylcholine Biochemistry Choline chemistry.chemical_compound Crystallography medicine.anatomical_structure Phosphorylethanolamine Models Chemical Deuterium Group (periodic table) Phosphatidylcholine Phosphodiester bond Phosphatidylcholines medicine Crystallization |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Biomembranes. 467:109-119 |
| ISSN: | 0005-2736 |
| DOI: | 10.1016/0005-2736(77)90188-2 |
| Popis: | The average orientation and flexibility of the phosphorylcholine group are deduced from deuterium and phosphorus-31 nuclear magnetic resonance measurements of unsonicated phosphatidylcholine bilayers in the liquid crystalline state. The experimental data are consistent with a model in which the polar head group exhibits a restricted flexibility characterized by rapid transitions between two enantiomeric conformations. A completely flexible or a completely rigid head group structure can be excluded. The phosphorylcholine residue is found to be bent at the position of the phosphate group, due to a gauche-gauche conformation of the phosphodiester linkage. The choline dipole is aligned parallel to the plane of the membrane, which is in agreement with X-ray and neutron diffraction studies. The average orientation of the phosphorylcholine group is therfore the same as that of the phosphorylethanolamine head group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|