Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
| Autor: | Abhishek D Garg, Lorenzo eGalluzzi, Lionel eApetoh, Thais eBaert, Raymond B Birge, Jose Manuel Bravo-San Pedro, Karine eBreckpot, David eBrough, Ricardo eChaurio, Mara eCirone, An eCoosemans, Pierre G Coulie, Dirk eDe Ruysscher, Luciana eDini, Peter ede Witte, Aleksandra M Dudek-Peric, Alberto eFaggioni, Jitka eFucikova, Udo S Gaipl, Jakub eGolab, Marie-Lise eGougeon, Michael R Hamblin, Akseli eHemminki, Martin eHerrmann, James W. Hodge, Oliver eKepp, Guido eKroemer, Dmitri V Krysko, Walter G Land, Frank eMadeo, Angelo A. Manfredi, Stephen R. Mattarollo, Christian eMaueroder, Nicolò eMerendino, Gabriele eMulthoff, Thomas ePabst, Jean-Ehrland eRicci, Chiara eRiganti, Erminia eRomano, Nicole eRufo, Mark J. Smyth, Jürgen eSonnemann, Radek eSpisek, John eStagg, Erika eVacchelli, Peter eVandenabeele, Lien eVandenberk, Benoit J Van Den Eynde, Stefaan Willy Van Gool, Francesca eVelotti, Laurence eZitvogel, Patrizia eAgostinis |
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| Přispěvatelé: | Research Programs Unit, Translational Cancer Biology (TCB) Research Programme, Medicum, Transplantation Laboratory, Garg, Ad, Galluzzi, L, Apetoh, L, Baert, T, Birge, Rb, Bravo San Pedro, Jm, Breckpot, K, Brough, D, Chaurio, R, Cirone, M, Coosemans, A, Coulie, Pg, De Ruysscher, D, Dini, L, de Witte, P, Dudek Peric, Am, Faggioni, A, Fucikova, J, Gaipl, U, Golab, J, Gougeon, Ml, Hamblin, Mr, Hemminki, A, Herrmann, M, Hodge, Jw, Kepp, O, Kroemer, G, Krysko, Dv, Land, Wg, Madeo, F, Manfredi, ANGELO ANDREA M. A., Mattarollo, Sr, Maueroder, C, Merendino, N, Multhoff, G, Pabst, T, Ricci, Je, Riganti, C, Romano, E, Rufo, N, Smyth, Mj, Sonnemann, J, Spisek, R, Stagg, J, Vacchelli, E, Vandenabeele, P, Vandenberk, L, Van den Eynde, Bj, Van Gool, S, Velotti, F, Zitvogel, L, Agostinis, P., Dini, Luciana, Manfredi, Aa, Medicine and Pharmacy academic/administration, Laboratory of Molecullar and Cellular Therapy, Basic (bio-) Medical Sciences, Chemistry, UCL - SSS/DDUV - Institut de Duve |
| Jazyk: | angličtina |
| Předmět: |
medicine.medical_treatment
APOPTOTIC CALRETICULIN EXPOSURE anti-tumor immunity immunogenicity PHOTODYNAMIC THERAPY 0302 clinical medicine translational medicine oncoimmunology Immunology and Allergy Cytotoxic T cell Medicine Anti-tumor immunity Immunogenicity Immunotherapy Molecular medicine Oncoimmunology Patient prognosis Translational medicine Immunology 0303 health sciences immunotherapy molecular medicine patient prognosis RIBOSOMAL-PROTEIN DIMER Classification ddc 3. Good health 030220 oncology & carcinogenesis Immunogenic cell death Molecular Medicine ACTIVATING POLYPEPTIDE-II HIGH HYDROSTATIC-PRESSURE lcsh:Immunologic diseases. Allergy ANTICANCER IMMUNE-RESPONSES 3122 Cancers 610 Medicine & health 03 medical and health sciences Immune system HUMAN TUMOR-CELLS FORMYL PEPTIDE RECEPTORS 030304 developmental biology business.industry Biology and Life Sciences CYTOTOXIC T-LYMPHOCYTES Dendritic cell NEGATIVE BREAST-CANCER Cancer cell molecular dicine 3111 Biomedicine business lcsh:RC581-607 |
| Zdroj: | Frontiers in Immunology, Vol 6 (2015) Garg, Abhishek D; Galluzzi, Lorenzo; Apetoh, Lionel; Baert, Thais; Birge, Raymond B; Bravo-San Pedro, José Manuel; Breckpot, Karine; Brough, David; Chaurio, Ricardo; Cirone, Mara; Coosemans, An; Coulie, Pierre G; De Ruysscher, Dirk; Dini, Luciana; de Witte, Peter; Dudek-Peric, Aleksandra M; Faggioni, Alberto; Fucikova, Jitka; Gaipl, Udo S; Golab, Jakub; ... (2015). Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death. Frontiers in immunology, 6(588), p. 588. Frontiers Research Foundation 10.3389/fimmu.2015.00588 Frontiers in Immunology FRONTIERS IN IMMUNOLOGY University of Manchester-PURE Frontiers in Immunology, Vol. 6, p. 588 (2015) |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2015.00588 |
| Popis: | The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other immunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation. ispartof: Frontiers in Immunology vol:6 issue:NOV ispartof: location:Switzerland status: published |
| Databáze: | OpenAIRE |
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