Comparison of Japanese Encephalitis Force of Infection in Pigs, Poultry and Dogs in Cambodian Villages
| Autor: | Benoit Durand, Heidi Auerswald, Veasna Duong, Sowath Ly, Leangyi Heng, Héléna Ladreyt, Chakriyouth Top, Sokchea Lay, Philippe Dussart, Saraden In, Sreymom Ken, Sothyra Tum, Véronique Chevalier |
|---|---|
| Přispěvatelé: | Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire de santé animale, sites de Maisons-Alfort et de Dozulé, Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Ministry of Agriculture, Forestry and Fisheries [Cambodia], Immunologie [Phnom Penh], Unité d'Épidémiologie et de Santé Publique [Phnom Penh], Département Systèmes Biologiques (Cirad-BIOS), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), This research was funded by the French Ministry of Agriculture, the International Center of Research in Agriculture for Development (CIRAD), Institut Pasteur du Cambodge, the French Agency for Food, Environmental and Occupational Health and Safety (ANSES) and the Swedish Research Council. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Veterinary medicine
viruses [SDV]Life Sciences [q-bio] lcsh:Medicine Force of infection L73 - Maladies des animaux Porcin 0302 clinical medicine Immunology and Allergy 2. Zero hunger 0303 health sciences Virulence biology Mortality rate Multi-host virus diseases 3. Good health Épidémiologie Infectious Diseases Maladie des animaux S50 - Santé humaine dog Cambodia Microbiology (medical) Culex Pouvoir pathogène 030231 tropical medicine Chien Volaille Article Virus Virus des animaux 03 medical and health sciences Dogs medicine Seroprevalence Molecular Biology MESH: Encephalitis Virus Japanese Hemagglutination assay [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health General Immunology and Microbiology 030306 microbiology Flavivirus Viral encephalitis lcsh:R Japanese encephalitis medicine.disease biology.organism_classification Japanese encephalitis virus Virus encéphalite japonaise [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| Zdroj: | Pathogens Pathogens, MDPI, 2020, 9 (9), pp.719. ⟨10.3390/pathogens9090719⟩ Pathogens, Vol 9, Iss 719, p 719 (2020) Volume 9 Issue 9 |
| ISSN: | 2076-0817 |
| Popis: | Japanese encephalitis virus (JEV) is the main cause of human viral encephalitis in Asia, with a mortality rate reaching 30%, mostly affecting children. The traditionally described cycle involving wild birds as reservoirs, pigs as amplifying hosts and Culex mosquitoes as vectors is questioned, with increasing evidence of a more complex multi-host system involved in areas where densities of pigs are low, such as in Cambodia. In 2018, we examined pigs, chickens, ducks and dogs from Kandal province, Cambodia, for antibody response against JEV by hemagglutination inhibition and virus neutralization assays. Forces of infection (FOI) for flaviviruses and JEV were estimated per species and per unit of body surface area (BSA). JEV seroprevalence reached 31% (95% CI: 23&ndash 41%) in pigs, 1% (95% CI: 0.1&ndash 3%) in chickens, 12% (95% CI: 7&ndash 19%) in ducks and 35% (95% CI: 28&ndash 42%) in dogs. Pigs were most likely to be infected (FOI: 0.09 per month), but the FOI was higher in ducks than in pigs for a given BSA (ratio of 0.13). Dogs had a lower FOI than ducks but a higher FOI than chickens (0.01 per month). For a given BSA, dogs were less likely to be infected than pigs (ratio of 1.9). In Cambodia, the virus may be circulating between multiple hosts. Dogs live in close contact with humans, and estimating their exposure to JEV infection could be a relevant indicator of the risk for humans to get infected, which is poorly known due to underdiagnosis. Understanding the JEV cycle and developing tools to quantify the exposure of humans is essential to adapt and support control measures for this vaccine-preventable disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|