Prognostic significance of lymphovascular space invasion for stage IA1 and IA2 cervical cancer
| Autor: | Ana I. Tergas, Jason D. Wright, B. Margolis, Ling Chen, Kayla Cagle-Colon, Leslie R. Boyd |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Uterine Cervical Neoplasms Internal medicine medicine Carcinoma Humans Stage (cooking) Cervix Aged Retrospective Studies Cervical cancer business.industry Obstetrics and Gynecology Cancer Middle Aged Prognosis medicine.disease United States Lymphovascular Squamous carcinoma medicine.anatomical_structure Lymphatic Metastasis Adenocarcinoma Female Lymph Nodes business |
| Zdroj: | International Journal of Gynecologic Cancer. 30:735-743 |
| ISSN: | 1525-1438 1048-891X |
| DOI: | 10.1136/ijgc-2019-000849 |
| Popis: | BackgroundData regarding the prognostic significance of lymphovascular space invasion (LVSI) for stage IA1 and IA2 cervical cancer are limited. Specifically, the role of LVSI as an independent risk factor for mortality in stage IA disease has not been shown.ObjectiveWe examined the association between LVSI and nodal metastases and survival for women with stage IA1 and IA2 cervical cancer.Study DesignWe used the National Cancer Database to identify patients with stage IA adenocarcinoma or squamous carcinoma of the cervix from January 2010 through December 2015 for whom LVSI status was known. Mixed-effect log-Poisson models were used to identify predictors of LVSI. Cox proportional hazard models and Kaplan-Meier curves were used to compare all-cause mortality.ResultsWe identified 3239 patients with stage IA1 and 1049 patients with stage IA2 carcinoma of the cervix. Among patients with stage IA1 and IA2 disease, 10.5% and 18.8% had LVSI, respectively. Less than 1% of patients with stage IA1 disease without LVSI had positive nodes compared with 7.8% of those with LVSI (pConclusionsLVSI is associated with lymph node metastases in patients with stage IA cervical cancer. LVSI is associated with decreased survival for women with stage IA2 cervical cancer. |
| Databáze: | OpenAIRE |
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