The relationship between pKa and skin irritation for a series of basic penetrants in man
| Autor: | Bret Berner, Robert J. Steffens, Wilson Donald R, Robert S. Hinz, Gerard C. Mazzenga, Howard I. Maibach, Richard H. Guy |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Erythema Chemical Phenomena Skin Absorption Human skin In Vitro Techniques Toxicology medicine.disease_cause Skin Diseases Penetrant (mechanical electrical or structural) Edema medicine Humans Chromatography High Pressure Liquid Skin integumentary system Chemistry Chemistry Physical Penetration (firestop) Middle Aged Dermatology Skin irritation Irritants Female medicine.symptom Irritation |
| Zdroj: | Fundamental and applied toxicology : official journal of the Society of Toxicology. 15(4) |
| ISSN: | 0272-0590 |
| Popis: | For a series of bases, which penetrate through human skin in vitro at similar rates (0.056–0.49 μ m /cm 2 /hr), penetrant p K a is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and redness measurements are highly linearly correlated. For the selected series, irritation becomes significant for bases with a p K a > 8. The irritation potential of acids with p K a ≤ 4 has been previously reported; p K a appears highly predictive of acute skin irritation for acids and bases in man. |
| Databáze: | OpenAIRE |
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