Circadian rhythms affect bone reconstruction by regulating bone energy metabolism

Autor:	Guangxia Feng, Lili Chen, Shue Li, Qingming Tang, Xin Zhou, Ying Yin, Beibei Luo
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Period (gene) Circadian clock Review Biology Bone and Bones General Biochemistry Genetics and Molecular Biology Osteogenesis Circadian Clocks Animals Circadian rhythm Bone General Medicine Circadian clock gene Cell biology CLOCK PER2 Skeleton formation PER3 Metabolism Bone formation Osteoclast Medicine Energy Metabolism Transcription Factors Cryptochrome-1 PER1
Zdroj:	Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-15 (2021) Journal of Translational Medicine
ISSN:	1479-5876
Popis:	Metabolism is one of the most complex cellular biochemical reactions, providing energy and substances for basic activities such as cell growth and proliferation. Early studies have shown that glucose is an important nutrient in osteoblasts. In addition, amino acid metabolism and fat metabolism also play important roles in bone reconstruction. Mammalian circadian clocks regulate the circadian cycles of various physiological functions. In vertebrates, circadian rhythms are mediated by a set of central clock genes: muscle and brain ARNT like-1 (Bmal1), muscle and brain ARNT like-2 (Bmal2), circadian rhythmic motion output cycle stagnates (Clock), cryptochrome 1 (Cry1), cryptochrome2 (Cry2), period 1 (Per1), period 2 (Per2), period 3 (Per3) and neuronal PAS domain protein 2 (Npas2). Negative feedback loops, controlled at both the transcriptional and posttranslational levels, adjust these clock genes in a diurnal manner. According to the results of studies on circadian transcriptomic studies in several tissues, most rhythmic genes are expressed in a tissue-specific manner and are affected by tissue-specific circadian rhythms. The circadian rhythm regulates several activities, including energy metabolism, feeding time, sleeping, and endocrine and immune functions. It has been reported that the circadian rhythms of mammals are closely related to bone metabolism. In this review, we discuss the regulation of the circadian rhythm/circadian clock gene in osteoblasts/osteoclasts and the energy metabolism of bone, and the relationship between circadian rhythm, bone remodeling, and energy metabolism. We also discuss the therapeutic potential of regulating circadian rhythms or changing energy metabolism on bone development/bone regeneration.
Databáze:	OpenAIRE
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