Differential effects of electrical stimulation patterns, motivational-behavioral stimuli and their order of application on functional plasticity processes within one input in the dentate gyrus of freely moving rats in vivo
| Autor: | Jorge A. Bergado, W. Almaguer-Melian, J. López-Rojas, Julietta U. Frey, Sabine Frey |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Time Factors Long-Term Potentiation Models Neurological Perforant Pathway Stimulus (physiology) Neurotransmission Animals Neurons Afferent Rats Wistar Long-term depression Analysis of Variance Motivation Behavior Animal Water Deprivation musculoskeletal neural and ocular physiology General Neuroscience Dentate gyrus Long-term potentiation Electric Stimulation Electrodes Implanted Rats nervous system Protein Biosynthesis Dentate Gyrus Synapses Synaptic plasticity Excitatory postsynaptic potential Psychology Neuroscience Synaptic tagging |
| Zdroj: | Neuroscience. 165:1546-1558 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2009.11.068 |
| Popis: | Hippocampal long-term potentiation (LTP) is a long-lasting increase in synaptic efficacy considered to be the cellular basis of memory. LTP consists of an early, protein synthesis-independent phase (E-LTP) and a late phase that depends on protein synthesis (L-LTP). In water-deprived rats E-LTP in the dentate gyrus (DG) can be reinforced into L-LTP, if the rats were allowed to drink within 15 min after E-LTP induction (behavioral LTP-reinforcement, BR). LTP can be depotentiated by low-frequency stimulation (LFS) to the same synaptic input if applied shortly after tetanization ( |
| Databáze: | OpenAIRE |
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