Significance of P16INK4A hypermethylation gene in primary head/neck and colorectal tumors: it is a specific tissue event? Results of a 3-year GOIM (Gruppo Oncologico dell'Italia Meridionale) prospective study
| Autor: | Rosa Maria Tomasino, V. Adamo, Antonio Russo, Federica Latteri, Maria Rosaria Valerio, Gaetana Rinaldi, Mario Adelfio Latteri, Donatella Calcara, Loredana Bruno, Vincenza Morello, Vito Rodolico, G. Di Fede, Nello Grassi, Giuseppe Altavilla, Eugenio Fiorentino, Viviana Bazan, Valentina Agnese, Antonino Agrusa, Adele Crosta, Giuseppe Cicero, Corsale S, Giuseppe Colucci, Claudia Augello, Valentina Calò |
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| Přispěvatelé: | AGNESE V, CORSALE S, CALO V, AUGELLO C, BRUNO L, CALCARA D, CROSTA A, RODOLICO V, RINALDI G, CICERO G, LATTERI F, AGRUSA A, MORELLO V, ADAMO V, ALTAVILLA G, DI FEDE G, FIORENTINO E, GRASSI N, LATTERI M, VALERIO MR, TOMASINO RM, COLUCCI G, BAZAN V, RUSSO A |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Oncology
medicine.medical_specialty Colorectal cancer Internal medicine medicine Humans Promoter Regions Genetic Prospective cohort study Neoplasm Staging Univariate analysis business.industry Genes p16 Incidence (epidemiology) Cancer Hematology Methylation DNA Methylation medicine.disease Head and Neck Neoplasms Salivary gland cancer DNA methylation Carcinoma Squamous Cell Colorectal Neoplasms business P16INK4A head and neck carcinoma |
| Popis: | Background Methylation of the p16 promoter is one of the most frequent mechanisms of gene inactivation; its incidence is extremely variable according to the type of tumor involved. Our purpose was to analyze the hypermethylation of the p16 promoter in laryngeal squamous cell carcinomas (LSCC), salivary gland (SG) tumors and in colorectal cancer (CRC), to detect any possible association with the clinicopathological features and to determine the prognostic significance of the p16 gene in the tumors analyzed. Patients and methods The hypermethylation of the p16 promoter was prospectively analyzed, by MSP, in a consecutive series of 64 locally advanced LSCC patients, in a consecutive series of 33 SG tumor patients and in a consecutive series of 66 sporadic CRC patients. Results Hypermethylation was observed in 9% of the LSCC cases, in all cases of SG cancer and in 21% of the CRC cases. No significant association was observed between p16 hypermethylation and clinicopathological variables in all the tissue samples analyzed. Moreover at univariate analysis p16 mutations were not independently related at disease relapse and death in LSCC and CRC. Conclusions The results of this study suggest that the lack of p16 function could happen in advanced stage of SG tumors. |
| Databáze: | OpenAIRE |
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