Conjugation of a Scintillator Complex and Gold Nanorods for Dual-Modal Image-Guided Photothermal and X-ray-Induced Photodynamic Therapy of Tumors
| Autor: | Li Luo, Xiangmei Liu, Jinghui Zhang, Dandan Ding, Xiaoyuan Chen, Hongmin Chen, Tianhang Shi, Ruixue Qin, Wenjing Sun, Yushuo Feng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Radiation-Sensitizing Agents
Materials science Nir light Combination therapy Cell Survival medicine.medical_treatment Antineoplastic Agents Nanotechnology Photodynamic therapy 02 engineering and technology Scintillator 010402 general chemistry Lanthanoid Series Elements 01 natural sciences Theranostic Nanomedicine Mice Cell Line Tumor medicine Animals General Materials Science Tumor growth Fluorescent Dyes Mice Inbred BALB C Nanotubes X-Rays Optical Imaging X-ray Photothermal therapy 021001 nanoscience & nanotechnology 0104 chemical sciences Photochemotherapy Nanorod Gold 0210 nano-technology |
| Zdroj: | ACS Applied Materials & Interfaces. 12:12591-12599 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.0c01189 |
| Popis: | Light-mediated therapy has many unique merits but monotherapy strategies rarely completely inhibit tumor growth because resistance often develops. Combination therapy is a promising strategy in oncology and has demonstrated superior safety and efficacy over monotherapy. Here, we conjugated a scintillator complex and gold nanorod nanosensitizer for dual-modal image-guided photothermal and X-ray-induced photodynamic therapy (PDT). Lanthanide complexes were successfully conjugated and offer excellent X-ray-excited optical luminescence for PDT effects. The strong near-infrared (NIR) light and X-ray absorption abilities of gold nanorods make the nanosensitizer function as both a photothermal agent for photothermal therapy and a radiosensitizer for enhanced radiotherapy. The studies in vitro and in vivo demonstrated that the nanosensitizer offers good dual-modal imaging capability and significantly suppresses tumor progression under NIR light and X-ray irradiation. This work shows the great potential of conjugating scintillator lanthanide complexes and gold nanosensitizers for multimodal image-guided therapy of deep-seated tumors. |
| Databáze: | OpenAIRE |
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